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Open AccessShared decision making, prospektive Lebensqualität und das beste Interesse des Kindes: ethische Herausforderungen im Kontext von Behandlungsentscheidungen bei Frühgeborenen an der Grenze der Lebensfähigkeit
Behandlungsentscheidungen bei Frühgeburten an der Grenze der Lebensfähigkeit stellen eine große Herausforderung dar. In der Neonatologie hat sich das Konzept einer prognostischen Grauzone etabliert, die als ei...
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Article
Open AccessALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2. Despite being an amenab...
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Article
Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
There are two errors and one omission in the original article. Author Gottardo’s correct name is Nicholas G. Gottardo, author Hulleman’s correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements...
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Article
Open AccessThe ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion
Astroblastomas are rare brain tumours which predominate in children and young adults, and have a controversial claim as a distinct entity, with no established WHO grade. Reports suggest a better outcome than h...
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Article
Open AccessOutcomes of endoscopic management of primary and refractory postcholecystectomy biliary leaks in a multicentre review of 178 patients
Biliary leaks have been treated with endoscopic management using different techniques with conflicting results. Furthermore the appropriate rescue therapy for refractory leaks has not been established. We eval...
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Article
Open AccessThe prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma
Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As function...
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Article
Open AccessThe mirror neuron system in post-stroke rehabilitation
Different treatments for stroke patients have been proposed; among them the mirror therapy and motion imagery lead to functional recovery by providing a cortical reorganization. Up today the basic concepts of ...
