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Article
Open AccessThe genetic landscape of immune-competent and HIV lymphoma
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Article
Open AccessA comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes
Human erythrocytes are terminally differentiated, anucleate cells long thought to lack RNAs. However, previous studies have shown the persistence of many small-sized RNAs in erythrocytes. To comprehensively de...
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Article
Open AccessPathosphere.org: pathogen detection and characterization through a web-based, open source informatics platform
The detection of pathogens in complex sample backgrounds has been revolutionized by wide access to next-generation sequencing (NGS) platforms. However, analytical methods to support NGS platforms are not as un...
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Article
Open AccessC/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event
Therapeutic targeting of specific genetic changes in cancer has proven to be an effective therapy and the concept of synthetic lethality has emerged. CCAAT/enhancer-binding protein-β (C/EBPβ), a basic leucine ...
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Article
Open AccessMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birt...
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Open AccessTranscriptomic and life history responses of the mayfly Neocloeon triangulifer to chronic diel thermal challenge
To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood u...
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Open AccessAssociation between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the di...
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Open AccessDNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unkn...
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Open AccessTranscriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
Cadmium (Cd) is a ubiquitous toxic heavy metal of major public concern. Despite inefficient placental transfer, maternal Cd exposure impairs fetal growth and development. Increasing evidence from animal models...
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Open AccessAnalysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molec...
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Open AccessMaternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed...
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Article
Open AccessDNA methylation of imprint control regions associated with Alzheimer’s disease in non-Hispanic Blacks and non-Hispanic Whites
Alzheimer’s disease (AD) prevalence is twice as high in non-Hispanic Blacks (NHBs) as in non-Hispanic Whites (NHWs). The objective of this study was to determine whether aberrant methylation at imprint control...
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Open AccessCreation and validation of the first infinium DNA methylation array for the human imprintome
Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formati...
