5 Result(s)

Article

Correction: Path-level interpretation of Gaussian graphical models using the pair-path subscore

Nathan P. Gill, Raji Balasubramanian, James R. Bain… in BMC Bioinformatics (2022)

Article

Path-level interpretation of Gaussian graphical models using the pair-path subscore

Construction of networks from cross-sectional biological data is increasingly common. Many recent methods have been based on Gaussian graphical modeling, and prioritize estimation of conditional pairwise depen...

Nathan P. Gill, Raji Balasubramanian, James R. Bain… in BMC Bioinformatics (2022)

Article

Transversions have larger regulatory effects than transitions

Transversions (Tv’s) are more likely to alter the amino acid sequence of proteins than transitions (Ts’s), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the...

Cong Guo, Ian C. McDowell, Michael Nodzenski, Denise M. Scholtens… in BMC Genomics (2017)

Article

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based o...

Anna C. Reisetter, Michael J. Muehlbauer, James R. Bain… in BMC Bioinformatics (2017)

Article

Human rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects

Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA met...

Peter McErlean, Silvio Favoreto Jr, Fabricio F Costa, Junqing Shen… in BMC Medical Genomics (2014)