31 Result(s)

Article

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...

Anqi Wang, Jiayi Shen, Alex A. Rodriguez, Edward J. Saunders, Fei Chen… in Nature Genetics (2023)

Article

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, iden...

Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law… in Nature Genetics (2023)

Article

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loc...

**young Byun, Younghun Han, Yafang Li, Jun **a, Er** Long… in Nature Genetics (2022)

Article

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studie...

David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders… in Nature Genetics (2021)

Article

Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’

Weiyin Zhou, Mitchell J. Machiela, Neal D. Freedman, Nathaniel Rothman… in Nature Genetics (2019)

Article

Discovery of common and rare genetic risk variants for colorectal cancer

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consor...

Jeroen R. Huyghe, Stephanie A. Bien, Tabitha A. Harrison, Hyun Min Kang… in Nature Genetics (2019)

Article

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Genome-wide association studies (GWAS) and fine-map** efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array...

Fredrick R. Schumacher, Ali Amin Al Olama, Sonja I. Berndt… in Nature Genetics (2018)

Article

Mosaic loss of chromosome Y is associated with common variation near TCL1A

Meredith Yeager, Stephen Chanock and colleagues analyze mosaic loss of the Y chromosome in three prospective cohorts and observe association with age and smoking but not with cancer survival. They also identif...

Weiyin Zhou, Mitchell J Machiela, Neal D Freedman, Nathaniel Rothman… in Nature Genetics (2016)

Article

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

James Cerhan and colleagues report genome-wide association and meta-analysis studies to identify genetic susceptibility loci for diffuse large B cell lymphoma. They identify four loci that influence genetic su...

James R Cerhan, Sonja I Berndt, Joseph Vijai, Hervé Ghesquières… in Nature Genetics (2014)

Article

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new sus...

Ali Amin Al Olama, Zsofia Kote-Jarai, Sonja I Berndt, David V Conti… in Nature Genetics (2014)

Article

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci.

Brian M Wolpin, Cosmeri Rizzato, Peter Kraft, Charles Kooperberg… in Nature Genetics (2014)

Article

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Richard Houlston, Maria Teresa Landi and colleagues report the identification of large-effect associations for squamous lung cancer with rare variants in BRCA2 and CHEK2.

Yufei Wang, James D McKay, Thorunn Rafnar, Zhaoming Wang… in Nature Genetics (2014)

Article

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.

Sonja I Berndt, Christine F Skibola, Vijai Joseph, Nicola J Camp… in Nature Genetics (2013)

Article

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conducti...

Marcel den Hoed, Mark Eijgelsheim, Tõnu Esko, Bianca J J M Brundel… in Nature Genetics (2013)

Article

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genoty** array

Rosalind Eeles and colleagues report meta-analysis of genome-wide association studies for prostate cancer and genoty** on the custom iCOGS array in 25,074 cases and 24,272 controls from 32 studies available ...

Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders… in Nature Genetics (2013)