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Article
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages
Liver X receptors (LXRs) which link lipid metabolism and inflammation, were overexpressed in experimental rheumatoid arthritis (RA) rats as observed in our previous studies, while suppression of LXRα by silybi...
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Article
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
Thymic egress is a crucial process for thymocyte maturation, strictly regulated by sphingosine-1-phosphate lyase (S1PL). Recently, cystathionine γ-lyase (CSE), one of the enzymes producing hydrogen sulfide (H2S),...
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Article
Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
Communication between glial cells has a profound impact on the pathophysiology of Alzheimer’s disease (AD). We reveal here that reactive astrocytes control cell distancing in peri-plaque glial nets, which rest...
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Article
The Effect of Temperature on the Current-Carrying Tribological Behaviour of C/Cu Contact Pairs in High Humidity Environments
The environmental temperature alters the frictional behaviour by changing the state of the current-carrying contact interface, which makes the electrical contact invalid. In this work, the effects of three dif...
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Article
Open AccessPhylogenomics and the rise of the angiosperms
Angiosperms are the cornerstone of most terrestrial ecosystems and human livelihoods1,2. A robust understanding of angiosperm evolution is required to explain their rise to ecological dominance. So far, the angio...
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Article
Performance evaluation of underground pipelines subjected to landslide thrust with fiber optic strain sensing nerves
High-accuracy deformation monitoring is crucial for investigating landslide–pipeline interaction problems, in which the fiber optic nerve system (FONS) holds enormous potential. This paper presents a theoretic...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
VO2@TiO2 Photocatalytic Switch
The sharp changes in optical and electrical properties in the VO2 metal–semiconductor phase transition are regarded as an on–off switch to regulate the photocatalytic performance of VO2@TiO2. As the switch is ON,...
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency
Glucose-6-phosphate isomerase (GPI) deficiency is a rare hereditary nonspherocytic hemolytic anemia caused by GPI gene variants. This disorder exhibits wide heterogeneity in its clinical manifestations and molecu...
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Article
Open AccessA nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features
The aim of this study is to develop a nomogram model for predicting the occurrence of intramyocardial hemorrhage (IMH) in patients with Acute Myocardial Infarction (AMI) following Percutaneous Coronary Interve...
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Article
Comprehensive analysis of phenylpropanoids and butylidenephthalides in Angelica sinensis (Oliv.) Diels from different regions and processing methods by high-performance liquid chromatography combined with chemometrics
Angelicae sinensis radix is commonly used in Chinese medicine and is also widely used as a spice and condiment in many countries. Due to the different geographical sources and processing methods, the contents ...
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Article
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that N6-methyladenosine (m6A) is ...
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Article
Open AccessEpigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma
Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using whole genome bisulfite sequencing (WGBS), we identify the transc...
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Article
Open AccessBiogeographic patterns of meio- and micro-eukaryotic communities in dam-induced river-reservoir systems
Although the Three Gorges Dam (TGD) is the world’s largest hydroelectric dam, little is known about the spatial–temporal patterns and community assembly mechanisms of meio- and micro-eukaryotes and its two sub...
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Article
Open AccessAnterior cervical discectomy and fusion with a zero-profile VA spacer device: a clinical and radiological study with two-year follow-up
A retrospective study.
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Article
Remarkable mitochondrial genome heterogeneity in Meniocus linifolius (Brassicaceae)
Detailed analyses of 16 genomes identified a remarkable acceleration of mutation rate, hence mitochondrial sequence and structural heterogeneity, in Meniocus linifolius (Brassicaceae).
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Article
Open AccessA biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients
Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinic...
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Chapter and Conference Paper
Theoretical Simulation and Application of High Frequency Electromagnetic Wave Propagation Logging
High frequency electromagnetic wave propagation logging technology is an important method in geophysical exploration. Since the dielectric constant of water is much greater than that of oil, gas, and rock matr...
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Chapter and Conference Paper
Effective Skill Learning on Vascular Robotic Systems: Combining Offline and Online Reinforcement Learning
Vascular robotic systems, which have gained popularity in clinic, provide a platform for potentially semi-automated surgery. Reinforcement learning (RL) is a appealing skill-learning method to facilitate autom...
