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Open AccessErratum to: Unraveling the clonal hierarchy of somatic genomic aberrations
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Clonal evolution of chemotherapy-resistant urothelial carcinoma
Mark Rubin, Francesca Demichelis and colleagues study the evolution of urothelial carcinomas by performing whole-exome sequencing of tumors collected from patients before and after chemotherapy. They find mark...
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Open AccessASEQ: fast allele-specific studies from next-generation sequencing data
Single base level information from next-generation sequencing (NGS) allows for the quantitative assessment of biological phenomena such as mosaicism or allele-specific features in healthy and diseased cells. S...
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Article
Open AccessUnraveling the clonal hierarchy of somatic genomic aberrations
Defining the chronology of molecular alterations may identify milestones in carcinogenesis. To unravel the temporal evolution of aberrations from clinical tumors, we developed CLONET, which upon estimation of ...