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    Article

    Clonal evolution of chemotherapy-resistant urothelial carcinoma

    Mark Rubin, Francesca Demichelis and colleagues study the evolution of urothelial carcinomas by performing whole-exome sequencing of tumors collected from patients before and after chemotherapy. They find mark...

    Bishoy M Faltas, Davide Prandi, Scott T Tagawa, Ana M Molina in Nature Genetics (2016)

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    Article

    Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

    Genome-wide DNA methylation analysis of metastatic biopsies from patients with castration-resistant prostate cancer reveals marked epigenetic differences between samples with adenocarcinoma and neuroendocrine ...

    Himisha Beltran, Davide Prandi, Juan Miguel Mosquera, Matteo Benelli in Nature Medicine (2016)

  3. Article

    Open Access

    ASEQ: fast allele-specific studies from next-generation sequencing data

    Single base level information from next-generation sequencing (NGS) allows for the quantitative assessment of biological phenomena such as mosaicism or allele-specific features in healthy and diseased cells. S...

    Alessandro Romanel, Sara Lago, Davide Prandi, Andrea Sboner in BMC Medical Genomics (2015)