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  1. Article

    Open Access

    Influence of corticosteroid treatment on CXCR4 expression in DLBCL

    CXCR4-targeted radioligand therapy (RLT) with [177Lu]Lu/[90Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease sta...

    Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer… in EJNMMI Research (2023)

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  2. Article

    Open Access

    Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules

    Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between...

    Francesco Cicone, David Viertl, Thibaut Denoël, Michael G. Stabin… in EJNMMI Research (2022)

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  3. Article

    Open Access

    Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice

    Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...

    Francesco Cicone, Silvano Gnesin, Thibaut Denoël, Thierry Stora… in EJNMMI Research (2019)

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  4. Article

    Open Access

    First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK

    Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RG...

    Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes… in EJNMMI Research (2017)

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