5 Result(s)
within
David M. Jablons
English
Immunology
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Article
Open AccessCK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signal...
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Article
Open AccessHedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas
Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of me...
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Article
Open AccessDetection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC).
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Article
Open AccessSMO expression level correlates with overall survival in patients with malignant pleural mesothelioma
Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for mo...
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Article
Roles of secreted frizzled-related proteins in cancer
The Wnt signaling pathway is implicated in a variety of biological processes ranging from developmental cell fate to human disease. The components involved in Wnt signaling have been under intense investigatio...
