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695 Result(s)
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Article
Open AccessPublisher Correction: Mechanisms underlying the interactions and adaptability of nitrogen removal microorganisms in freshwater sediments
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Article
FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo
Triple-negative breast cancer (TNBC) is characterized by high aggressiveness, heterogeneity, and poor prognosis. Programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, a crucial type of i...
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Prokaryotic expression, purification, and the in vitro and in vivo protection study of dehydrin WDHN2 from Triticum aestivum
Dehydrins proteins accumulate and play important protective roles in most plants during abiotic stresses. The objective of this study was to characterize a YSK2-type dehydrin gene, WDHN2, isolated from Triticum a...
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Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption
The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the underlying mechanisms remain elusive. Gut microbiota and metabolites have been suggested to mediate the metabolic chang...
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The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells
Cancer stem cells (CSCs) play an important role in metastasis development, tumor recurrence, and treatment resistance, and are essential for the eradication of cancer. Currently, therapies fail to eradicate CS...
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Open AccessMetabolic differences in MSTN and FGF5 dual-gene edited sheep muscle cells during myogenesis
Dynamic metabolic reprogramming occurs at different stages of myogenesis and contributes to the fate determination of skeletal muscle satellite cells (MuSCs). Accumulating evidence suggests that mutations in m...
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Abnormal Degraded Tapetum 1 (ADT1) is required for tapetal cell death and pollen development in rice
The timely degradation of tapetum, the innermost somatic anther cell layer in flowering plants, is critical for pollen development. Although several genes involved in tapetum development have been characterize...
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Open AccessMechanisms underlying the interactions and adaptability of nitrogen removal microorganisms in freshwater sediments
Microorganisms in eutrophic water play a vital role in nitrogen (N) removal, which contributes significantly to the nutrient cycling and sustainability of eutrophic ecosystems. However, the mechanisms underlyi...
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The role of soil microorganisms and physicochemical properties in determining the germinate of invasive Solidago canadensis L.
Several studies have shown that soil microorganisms and physicochemical properties are crucial for the successful colonisation of invasive plants. However, most researchers have focused merely on the impacts o...
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Ectopic expression of OsWOX9A alters leaf anatomy and plant architecture in rice
Ectopic expression of OsWOX9A induces narrow adaxially rolled rice leaves with larger bulliform cells and fewer large veins, probably through regulating the expression of auxin-related and expansin genes.
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MafG/MYH9-LCN2 axis promotes liver fibrosis through inhibiting ferroptosis of hepatic stellate cells
Hepatic stellate cells (HSCs) secrete extracellular matrix for collagen deposition, contributing to liver fibrosis. Ferroptosis is a novel type of programmed cell death induced by iron overload-dependent lipid...
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Open AccessSegregation of endosymbionts in complex symbiotic system of cicadas providing novel insights into microbial symbioses and evolutionary dynamics of symbiotic organs in sap-feeding insects
The most extraordinary systems of symbiosis in insects are found in the suborder Auchenorrhyncha of Hemiptera, which provide unique perspectives for uncovering complicated insect-microbe symbiosis. We investig...
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Open AccessA GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles
Physiologically, the atria contract first, followed by the ventricles, which is the prerequisite for normal blood circulation. The above phenomenon of atrioventricular sequential contraction results from the c...
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Effects of exotic detritus input on native litter breakdown in a eutrophic lake: investigating the home-field advantage
Invasive plants have been shown to alter ecosystem functions. However, there is limited information available on the effect of the invasive species litter input on native litter decomposition and home-field ad...
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Divergent intra- and interspecific root order variability identifies a two-dimensional root economics spectrum
The form-function linkages and variation of fine root traits reflect adaptive strategies to cope with complex soil environments. However, their contributions to the root economics spectrum (RES) remain unclear.
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Open AccessProximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury
Four-and-a-half LIM domains protein 2 (FHL2) is an adaptor protein that may interact with hypoxia inducible factor 1α (HIF-1α) or β-catenin, two pivotal protective signaling in acute kidney injury (AKI). Howev...
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Open AccessA novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression
Transforming growth factor beta (TGFβ) signaling plays a critical role in tumorigenesis and metastasis. However, little is known about the biological function of TGFbeta-induced lncRNA in cancer. In this study...
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Open AccessIsochorismate synthase is required for phylloquinone, but not salicylic acid biosynthesis in rice
Salicylic acid (SA) is a phytohormone required for plant growth and defense signaling. There are two major SA biosynthesis pathways in plants: the isochorismate synthase (ICS) pathway and the phenylalanine amm...
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Open AccessSeed germination demonstrates inter-annual variations in alkaline tolerance: a case study in perennial Leymus chinensis
The escalating issue of soil saline-alkalization poses a growing global challenge. Leymus chinensis is a perennial grass species commonly used in the establishment and renewal of artificial grasslands that is rel...
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Open AccessMorphological and molecular characterization of Eimeria haematopusi n. sp. (Apicomplexa: Eimeriidae) in an Australian Pied Oystercatcher (Haematopus longirostris) (Aves: Charadriiformes)
A novel Eimeria Schneider, 1875 species is described from an Australian pied oystercatcher Haematopus longirostris Vieillot, in Western Australia. The pied oystercatcher was admitted to the Kanyana Wildlife Rehab...