4 Result(s)
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Article
Open AccessStatistically efficient association analysis of quantitative traits with haplotypes and untyped SNPs in family studies
Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two m...
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Article
Open AccessI-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms
We propose a statistical boosting method, termed I-Boost, to integrate multiple types of high-dimensional genomics data with clinical data for predicting survival time. I-Boost provides substantially higher pr...
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Article
Open AccessPreMeta: a tool to facilitate meta-analysis of rare-variant associations
Meta-analysis is essential to the discovery of rare variants that influence complex diseases and traits. Four major software packages, namely MASS, MetaSKAT, RAREMETAL, and seqMeta, have been developed to perf...
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Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
