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  1. Article

    Open Access

    Statistically efficient association analysis of quantitative traits with haplotypes and untyped SNPs in family studies

    Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two m...

    Guoqing Diao, Dan-yu Lin in BMC Genetics (2020)

  2. Article

    Open Access

    I-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms

    We propose a statistical boosting method, termed I-Boost, to integrate multiple types of high-dimensional genomics data with clinical data for predicting survival time. I-Boost provides substantially higher pr...

    Kin Yau Wong, Cheng Fan, Maki Tanioka, Joel S. Parker, Andrew B. Nobel in Genome Biology (2019)

  3. Article

    Open Access

    PreMeta: a tool to facilitate meta-analysis of rare-variant associations

    Meta-analysis is essential to the discovery of rare variants that influence complex diseases and traits. Four major software packages, namely MASS, MetaSKAT, RAREMETAL, and seqMeta, have been developed to perf...

    Zheng-Zheng Tang, Paul Bunn, Ran Tao, Zhouwen Liu, Dan-Yu Lin in BMC Genomics (2017)