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  1. Article

    Open Access

    Sarcopenic Obesity and Cardiovascular Disease: An Overlooked but High-Risk Syndrome

    Sarcopenic obesity (SO), defined as the coexistence of excess fat mass and reduced skeletal muscle mass and strength, has emerged as an important cardiovascular risk factor, particularly in older adults. This ...

    Saeid Mirzai, Salvatore Carbone, John A. Batsis in Current Obesity Reports (2024)

  2. No Access

    Chapter

    Exercise in Specific Diseases: Heart Failure with Preserved Ejection Fraction

    Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly increasing form of HF, occurs primarily in older women, and is associated with high rates of morbidity, mortality, and health car...

    Bharathi Upadhya, Frank Edelmann in Textbook of Sports and Exercise Cardiology (2020)

  3. Article

    Open Access

    Increased skeletal intermuscular fat is associated with reduced exercise capacity in cancer survivors: a cross-sectional study

    Cancer survivors experience on average a 20% reduction in peak exercise capacity (VO2 peak) post-cancer treatment. Intermuscular fat (IMF) is a strong predictor of reduced exercise capacity in heart failure (HF) ...

    Kerryn W. Reding, Peter Brubaker, Ralph D’Agostino Jr, Dalane W. Kitzman in Cardio-Oncology (2019)

  4. No Access

    Article

    Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?

    Previous trials definitively established that lowering systolic blood pressure (BP) to 140 mmHg prevented heart failure (HF) exacerbations, but the potential benefits and risks of further BP reduction remain u...

    Bharathi Upadhya, Richard B. Stacey, Dalane W. Kitzman in Current Hypertension Reports (2019)

  5. Article

    Open Access

    Asymptomatic myocardial ischemia forecasts adverse events in cardiovascular magnetic resonance dobutamine stress testing of high-risk middle-aged and elderly individuals

    Current guidelines for assessing the risk of experiencing a hospitalized cardiovascular (CV) event discourage stress testing of asymptomatic individuals; however, these recommendations are based on evidence ga...

    R. Brandon Stacey, Trinity Vera in Journal of Cardiovascular Magnetic Resonan… (2018)

  6. No Access

    Article

    Therapy for heart failure with preserved ejection fraction: current status, unique challenges, and future directions

    Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF. Among elderly women, HFpEF comprises more than 80% of incident HF cases. Adverse outcomes—exercise intolerance, poor q...

    Bharathi Upadhya, Mark J. Haykowsky, Dalane W. Kitzman in Heart Failure Reviews (2018)

  7. No Access

    Article

    Physical function and exercise training in older patients with heart failure

  8. Older patients (aged ≥70 years) with heart failure (HF) have substantially impaired physical function and poor clinical outcomes

  9. ...

    Andrew J. Stewart Coats, Daniel E. Forman, Mark Haykowsky in Nature Reviews Cardiology (2017)

  10. No Access

    Article

    Management of Heart Failure with Preserved Ejection Fraction: Current Challenges and Future Directions

    Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF in patients older than 65 years. Among elderly women living in the community, HFpEF comprises nearly 90% of incident HF...

    Bharathi Upadhya, Dalane W. Kitzman in American Journal of Cardiovascular Drugs (2017)

  11. No Access

    Article

    Sarcopenic Obesity and the Pathogenesis of Exercise Intolerance in Heart Failure with Preserved Ejection Fraction

    Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure (HF) in older adults. The primary chronic symptom in patients with HFpEF, even when well compensated, is severe e...

    Bharathi Upadhya, Mark J. Haykowsky, Joel Eggebeen in Current Heart Failure Reports (2015)

  12. No Access

    Article

    Update on Heart Failure with Preserved Ejection Fraction

    Heart failure with preserved ejection fraction (HFPEF) is the most common form of heart failure (HF) in older adults, and is increasing in prevalence as the population ages. Morbidity and long-term mortality i...

    Scott L. Hummel, Dalane W. Kitzman in Current Cardiovascular Risk Reports (2013)

  13. No Access

    Article

    Frailty and multiple comorbidities in the elderly patient with heart failure: implications for management

    Heart failure (HF) in the elderly is a major public health problem, and its prevalence is rising. Outcomes of HF in the elderly have not changed in the past 2 decades despite the introduction of novel HF thera...

    Khalil Murad, Dalane W. Kitzman in Heart Failure Reviews (2012)

  14. Article

    Open Access

    Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure

    Older heart failure (HF) patients exhibit exercise intolerance during activities of daily living. We hypothesized that reduced lower extremity blood flow (LBF) due to reduced forward cardiac output would contr...

    Chirapa Puntawangkoon, Dalane W Kitzman in Journal of Cardiovascular Magnetic Resonan… (2009)

  15. Article

    Open Access

    Adverse effect of increased left ventricular wall thickness on five year outcomes of patients with negative dobutamine stress

    To determine if patients without dobutamine induced left ventricular wall motion abnormalities (WMA) but an increased LV end-diastolic wall thickness (EDWT) exhibit a favorable cardiac prognosis.

    Thomas F Walsh, Erica Dall'Armellina in Journal of Cardiovascular Magnetic Resonan… (2009)

  16. No Access

    Chapter

    Exercise Intolerance in Patients with Heart Failure: Role of Diastolic Dysfunction

    Most patients with severe left ventricular dysfunction have exercise intolerance. Maximal oxygen consumption during a standardized exercise protocol is an objective measure of exercise tolerance. Since oxygen ...

    Dalane W. Kitzman, Martin J. Sullivan in Diastolic Relaxation of the Heart (1994)