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Article
Open AccessA positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression
The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development of various human cancers by modifying diverse biological functions. However, the precise molecular mechani...
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Article
Open AccessKnowledgeNavigator: leveraging large language models for enhanced reasoning over knowledge graph
Large language models have achieved outstanding performance on various downstream tasks with their advanced understanding of natural language and zero-shot capability. However, they struggle with knowledge con...
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Article
Open AccessRisk prediction of cholangitis after stent implantation based on machine learning
The risk of cholangitis after ERCP implantation in malignant obstructive jaundice patients remains unknown. To develop models based on artificial intelligence methods to predict cholangitis risk more accuratel...
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Article
Open AccessUrine Proteomic Signatures of Mild Hypothermia Treatment in Cerebral Ischemia–Reperfusion Injury in Rats
Mild hypothermia (MH) is an effective measure to alleviate cerebral ischemia–reperfusion (I/R) injury. However, the underlying biological mechanisms remain unclear. This study set out to investigate dynamic ch...
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Article
Emerging biosensor probes for glycated hemoglobin (HbA1c) detection
Glycated hemoglobin (HbA1c), originating from the non-enzymatic glycosylation of βVal1 residues in hemoglobin (Hb), is an essential biomarker indicating average blood glucose levels over a period of 2 to 3 mon...
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Article
Open AccessAugmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11
The dysregulated mechanistic target of rapamycin complex 1 (mTORC1) signaling plays a critical role in ferroptosis resistance and tumorigenesis. However, the precise underlying mechanisms still need to be full...
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Article
Open AccessElucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses
Body weight and size are important economic traits in chickens. While many growth-related quantitative trait loci (QTLs) and candidate genes have been identified, further research is needed to confirm and char...
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Article
Zn do** for enhanced sodium-ion conductivity and air stability in Na3SbS4 solid electrolyte
Solid electrolytes equipped battery show promise in solving energy storage and ecological concerns owing to their excellent electrical conductivity and chemical stability. Only a limited number of substances s...
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Article
Open AccessDiagnostic performance of metagenomic next-generation sequencing for the detection of pathogens in cerebrospinal fluid in pediatric patients with central nervous system infection: a systematic review and meta-analysis
Detecting pathogens in pediatric central nervous system infection (CNSI) is still a major challenge in medicine. In addition to conventional diagnostic patterns, metagenomic next-generation sequencing (mNGS) s...
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Article
Open AccessThe evolutionary trajectories of specialized metabolites towards antiviral defense system in plants
Viral infections in plants pose major challenges to agriculture and global food security in the twenty-first century. Plants have evolved a diverse range of specialized metabolites (PSMs) for defenses against ...
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Chapter and Conference Paper
Lightweight Dialog State Tracking Methods Based on RoBERTa for Resource Constrained Dialog Systems
Dialog state tracking is a crucial component of task-oriented dialog systems. Pre-trained language models can effectively perform dialog state tracking for task-oriented dialog systems through model fine-tunin...
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Article
Open AccessTranscriptome and histological analyses on the uterus of freckle egg laying hens
In this study, we explored the characteristics and causes of freckle formation. We collected 15 normal and freckled eggs each for eggshell index testing and hypothesized that the structure and function of the ...
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Article
DMCA-GAN: Dual Multilevel Constrained Attention GAN for MRI-Based Hippocampus Segmentation
Precise segmentation of the hippocampus is essential for various human brain activity and neurological disorder studies. To overcome the small size of the hippocampus and the low contrast of MR images, a dual ...
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Article
Open AccessThe role of intraoperative neurophysiological monitoring in intramedullary spinal cord tumor surgery
Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%. As they are located very deep and frequently cause postoperative neurological complications, surgical resection...
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Article
Open AccessElucidation of the genetic determination of clutch traits in Chinese local chickens of the Laiwu Black breed
Egg laying rate (LR) is associated with a clutch, which is defined as consecutive days of oviposition. The clutch trait can be used as a selection indicator to improve egg production in poultry breeding. Howev...
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Article
Preclinical evaluation and pilot clinical study of [68Ga]Ga-THP-APN09, a novel PD-L1 targeted nanobody radiotracer for rapid one-step radiolabeling and PET imaging
Programmed cell death protein-1/ligand-1 (PD-1/L1) blockade has been a breakthrough in the treatment of patients with non-small cell lung cancer (NSCLC), but there is still a lack of effective methods to scree...
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Article
Unsupervised deep consistency learning adaptation network for cardiac cross-modality structural segmentation
Deep neural networks have recently been succeessful in the field of medical image segmentation; however, they are typically subject to performance degradation problems when well-trained models are tested in an...
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Article
Effects of different modifying agents on the preparation and properties of coagulants derived from excess sludge
The contents and kinds of oxygen-containing functional groups are very significant when preparing cationic hydrochar coagulants via graft copolymerization. Herein, the hydrothermal conditions to produce sludge...
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Article
Open AccessA task-unified network with transformer and spatial–temporal convolution for left ventricular quantification
Quantification of the cardiac function is vital for diagnosing and curing the cardiovascular diseases. Left ventricular function measurement is the most commonly used measure to evaluate the function of cardia...
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Article
Genome Analysis and Safety Assessment of Achromobacter marplatensis Strain YKS2 Strain Isolated from the Rumen of Yaks in China
Achromobacter marplatensis strain YKS2 isolated from the yak rumen has the feature of producing cellulose. This study aims to analyze the genome and safety of strain YKS2 in vivo, considering its future research ...
