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  1. No Access

    Article

    ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism

    Bacterial energy-coupling factor (ECF) transporters mediate ATP-dependent uptake of essential environmental micronutrients. Biochemical and fluorescence analyses now show that ATP binding promotes release of a...

    Nathan K Karpowich, ** Mei Song, Nicolette Cocco… in Nature Structural & Molecular Biology (2015)

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    Article

    Structure and mechanism of a pentameric formate channel

    The structure of the formate channel FocA from Vibrio cholerae reveals a pentamer, with each monomer possessing its own substrate translocation pore. The selectivity filter consists of a central constriction ring...

    Andrew B Waight, James Love, Da-Neng Wang in Nature Structural & Molecular Biology (2010)

  3. No Access

    Article

    Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures

    Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin-reuptake inhibitors (SSRIs) that are widely prescribed to treat depression. They bind to the presynaptic plasma membrane serotonin transporte...

    Zheng Zhou, Juan Zhen, Nathan K Karpowich… in Nature Structural & Molecular Biology (2009)