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Article
Open AccessKe Hsin Kuo: A distinguished scientist and great mentor
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Article
ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism
Bacterial energy-coupling factor (ECF) transporters mediate ATP-dependent uptake of essential environmental micronutrients. Biochemical and fluorescence analyses now show that ATP binding promotes release of a...
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Article
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins
The New York Consortium on Membrane Protein Structure (NYCOMPS) was formed to accelerate the acquisition of structural information on membrane proteins by applying a structural genomics approach. NYCOMPS compr...
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Article
Structure and mechanism of a pentameric formate channel
The structure of the formate channel FocA from Vibrio cholerae reveals a pentamer, with each monomer possessing its own substrate translocation pore. The selectivity filter consists of a central constriction ring...
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Article
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures
Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin-reuptake inhibitors (SSRIs) that are widely prescribed to treat depression. They bind to the presynaptic plasma membrane serotonin transporte...
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Protocol
Purification and Characterization of Transporter Proteins from Human Erythrocyte Membrane
Functions and biochemical properties of several membrane transporter proteins from human erythrocyte, in particular, the glucose transporter (Glut1) and anion exchanger (AE1, also called Band 3) have been exte...