914 Result(s)
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Open AccessThe behavioral phenotype of children and adolescents with attenuated non-ketotic hyperglycinemia, intermediate to good subtype
We aim to describe the behavioral phenotype of children and adolescents with the good to intermediate attenuated form of non-ketotic hyperglycinemia (NKH) and to explore associations between the behavioral phe...
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Open AccessScreening for lung cancer with computed tomography: protocol for systematic reviews for the Canadian Task Force on Preventive Health Care
Lung cancer is the leading cause of cancer deaths in Canada, and because early cancers are often asymptomatic screening aims to prevent mortality by detecting cancer earlier when treatment is more likely to be...
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Correction: Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation
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Hashimoto’s thyroiditis and renal transplant rejection
Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disorder that can disrupt thyroid function and homeostasis. As HT results from a dysregulated immune system, we hypothesized that these patients migh...
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Open AccessTowards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Anxiety disorders are increasingly prevalent, affect people’s ability to do things, and decrease quality of life. Due to lack of objective tests, they are underdiagnosed and sub-optimally treated, resulting in...
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Open AccessTobacco chewing and associated factors among a vulnerable youth population in Sri Lanka
Tobacco in any form kills millions of people every year. Tobacco addiction among youth shows an increasing trend while smokeless type is becoming more common. This study aimed to describe the lifestyle of chewing...
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Open AccessComparison of intermittent screening (using ultra-sensitive malaria rapid diagnostic test) and treatment (using a newly registered antimalarial pyronaridine-artesunate—PYRAMAX®) to standard intermittent preventive treatment with sulfadoxine-pyrimethamine for the prevention of malaria in pregnant women living in endemic areas: ULTRAPYRAPREG
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is an important malaria control strategy in sub-Saharan Africa. Indeed, it overcomes the risk of misdiagnosis due to lo...
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Open AccessAlcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects
Alcohol’s impact on telomere length, a proposed marker of biological aging, is unclear. We performed the largest observational study to date (in n = 245,354 UK Biobank participants) and compared findings with Men...
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Open AccessEpigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial
Although the currently available antidepressants are well established in the treatment of the major depressive disorder (MDD), there is strong variability in the response of individual patients. Reliable predi...
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Prurigo pigmentosa following a ketogenic diet: a case report
A 19-year-old female of South Asian descent presented with a three-day history of pruritic, clustered papules and vesicles on her abdomen, associated with significant pruritus and intermittent pain. She commen...
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Open AccessEvaluation of plasma tau and neurofilament light chain biomarkers in a 12-year clinical cohort of human prion diseases
Prion diseases are fatal neurodegenerative conditions with highly accurate CSF and imaging diagnostic tests, but major unmet needs for blood biomarkers. Using ultrasensitive immuno-assays, we measured tau and ...
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Open AccessPrecision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also highly co-morbid with other psychiatric disorders. Currently there are no objective measures, such as blood tests, used...
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Open AccessPRISMA-DTA for Abstracts: a new addition to the toolbox for test accuracy research
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Open AccessTowards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs
The biological fingerprint of environmental adversity may be key to understanding health and disease, as it encompasses the damage induced as well as the compensatory reactions of the organism. Metabolic and h...
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Tolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for autoimmune diseases
Autologous haematopoietic stem cell transplantation shows increasing promise as a therapeutic option for patients with treatment-refractory autoimmune disease, particularly systemic sclerosis and multiple scle...
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Open AccessTaking guidance from parents involved in a longitudinal birth cohort – the ROLO family advisory committee
The ROLO Study (Randomised cOntrol trial of a Low glycaemic index diet in pregnancy to prevent macrosomia) was a randomised control trial conducted between 2007 and 2011 to examine if a low glycaemic index (GI...
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Open AccessMitochondrial DNA content and oxidation in bipolar disorder and its role across brain regions
The underlying pathology of bipolar disorder remains unknown, though evidence is accumulating to support a role of mitochondrial dysfunction. In this study, we aim to investigate electron transport chain compl...
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Open AccessSpatial association between outdoor air pollution and lung cancer incidence in China
Lung cancer is the most common cancer in China. Previous studies have indicated that lung cancer incidence exhibits remarkable spatial heterogeneity, and lung cancer is related to outdoor air pollution. Howeve...
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Open AccessSteps toward more complete reporting of systematic reviews of diagnostic test accuracy: Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy (PRISMA-DTA)
Reporting standards in biomedical research have been shown to be suboptimal. The publication of the PRISMA statement has improved the completeness of reporting of systematic reviews, but several issues specifi...
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Open AccessTowards precision medicine for pain: diagnostic biomarkers and repurposed drugs
We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design....
