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  1. Article

    Open Access

    A phase I study of bendamustine hydrochloride administered day 1+2 every 3 weeks in patients with solid tumours

    The aim of the study was to determine the maximum tolerated dose (MTD), the dose limiting toxicity (DLT), and the pharmacokinetic profile (Pk) of bendamustine (BM) on a day 1 and 2 every 3 weeks schedule and to r...

    M Rasschaert, D Schrijvers, J Van den Brande, J Dyck… in British Journal of Cancer (2007)

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  2. No Access

    Article

    Pharmacokinetics of MEN-10755, a novel anthracycline disaccharide analogue, in two phase I studies in adults with advanced solid tumours

    The doxorubicin analogue MEN-10755 has been identified as a compound with promising antitumour activity based on structure-activity studies of a new series of anthracycline disaccharides. The high antitumour ...

    A. Bos, E. Vries, P. Dombernovsky, S. Aamdal… in Cancer Chemotherapy and Pharmacology (2001)

  3. No Access

    Article

    Factors determining the place of palliative care and death of cancer patients

     Factors determining the place of palliative care and death were studied by interviewing 40 patients using a semi-structured questionnaire. The 86 interviews assessed showed that both emotional and somatic fac...

    B. Van den Eynden, I. Hermann, D. Schrijvers, P. Van Royen… in Supportive Care in Cancer (2000)

  4. Article

    Open Access

    Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature

    Ifosfamide is an alkylating agent used in the treatment of a variety of solid tumours. Ten to 15% of patients treated with ifosfamide develop an encephalopathy. Methylene blue (MB) may be used in the treatment...

    J Pelgrims, F De Vos, J Van den Brande, D Schrijvers, A Prové… in British Journal of Cancer (2000)

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  5. No Access

    Article

    Phase I study on docetaxel and ifosfamide in patients with advanced solid tumours

    Docetaxel and ifosfamide have shown significant activity against a variety of solid tumours. This prompted a phase I trial on the combination of these drugs. This phase I study was performed to assess the feas...

    LC Pronk, D Schrijvers, JHM Schellens, EA de Bruijn… in British Journal of Cancer (1998)

  6. No Access

    Chapter

    The management of ovarian cancer

    A 52-year-old, postmenopausal woman presented to her gynecologist in October 1986 with fatigue, abdominal distention and intermittent vaginal bleeding. Pelvic examination revealed a right adnexal mass. She had...

    A. M. Prové, L. Y. Dirix, D. Schrijvers… in The Teaching Cases from Annals of Oncology (1997)