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  1. No Access

    Article

    N-acetylphytosphingosine-induced apoptosis of Jurkat cells is mediated by the conformational change in Bak

    N-acetylphytosphingosine (NAPS), a sphingolipid derivative, is one of the well-known signal molecules that mediates various cellular functions, including cell growth, differentiation, and apoptosis. In this st...

    Y. Han, Y. Kim, H. Kang, S. H. Hong, Y. H. Kim, D. -S. Lim, C. Park… in Apoptosis (2006)

  2. No Access

    Article

    TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial–mesenchymal transition

    TMPRSS4 is a novel type II transmembrane serine protease found at the cell surface that is highly expressed in pancreatic, colon and gastric cancer tissues. However, the biological functions of TMPRSS4 in canc...

    H Jung, K P Lee, S J Park, J H Park, Y-s Jang, S-Y Choi, J-G Jung, K Jo… in Oncogene (2008)

  3. No Access

    Article

    Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1–S transition

    The tumor suppressor RASSF1A is inactivated in many human cancers and is implicated in regulation of microtubule stability, cell cycle progression and apoptosis. However, the precise mechanisms of RASSF1A acti...

    M S Song, S J Song, S J Kim, K Nakayama, K I Nakayama, D-S Lim in Oncogene (2008)

  4. No Access

    Article

    PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression

    Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulat...

    Y Lee, S J Kim, H D Park, E H Park, S M Huang, S B Jeon, J-M Kim, D-S Lim… in Oncogene (2010)

  5. No Access

    Article

    Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation

    Pancreatic adenocarcinoma upregulated factor (PAUF) is overproduced in certain types of cancer. However, little is known of the tumorigenic function of PAUF. In this study, we report the X-ray crystal structur...

    H D Park, Y Lee, Y K Oh, J G Jung, Y W Park, K Myung, K-H Kim, S S Koh, D-S Lim in Oncogene (2011)

  6. Article

    Open Access

    RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer

    The transcription coactivator Yes-associated protein 1 (YAP1) is regulated by the Hippo tumor suppressor pathway. However, the role of YAP1 in thyroid cancer, which is frequently associated with the BRAFV600E mut...

    S E Lee, J U Lee, M H Lee, M J Ryu, S J Kim, Y K Kim, M J Choi, K S Kim… in Oncogenesis (2013)

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