11 Result(s)

Article

Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays

Melanoma is one of the most aggressive types of cancer and resection of the tumour prior to dissemination of tumour cells is still the most effective treatment. Therefore, early diagnosis of melanocytic lesion...

N J W de Wit, J Rijntjes, J H S Diepstra, T H van Kuppevelt… in British Journal of Cancer (2005)

Article

High tPA-expression in primary melanoma of the limb correlates with good prognosis

To investigate whether the course of primary melanoma disease correlates with expression of the various components of the proteolytic plasminogen activation (PA) system, immunohistochemical stainings for activ...

C M Ferrier, S Suciu, W L van Geloof, H Straatman… in British Journal of Cancer (2000)

Article

Melanoma-inhibiting activity (MIA) mRNA is not exclusively transcribed in melanoma cells: low levels of MIA mRNA are present in various cell types and in peripheral blood

The detection of minimal amounts of melanoma cells by tyrosinase reverse transcription polymerase chain reaction (RT-PCR) is seriously hampered by false negative reports in blood of melanoma patients with diss...

T J de Vries, A Fourkour, C J A Punt, H Diepstra, D J Ruiter… in British Journal of Cancer (1999)

Article

Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumour progression and metastasis. In this study, we investigated the in vitro and in vivo expression patterns of MMP-1, MMP...

U B Hofmann, J R Westphal, E T Waas, A J W Zendman… in British Journal of Cancer (1999)

Article

Reproducibility of detection of tyrosinase and MART-1 transcripts in the peripheral blood of melanoma patients: a quality control study using real-time quantitative RT-PCR

In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melano...

T J de Vries, A Fourkour, C J A Punt, L T F van de Locht… in British Journal of Cancer (1999)

Article

Comparison of immunohistochemistry with immunoassay (ELISA) for the detection of components of the plasminogen activation system in human tumour tissue

Enzyme-linked immunosorbent assay (ELISA) methods and immunohistochemistry (IHC) are techniques that provide information on protein expression in tissue samples. Both methods have been used to investigate the ...

C M Ferrier, H H de Witte, H Straatman, D H van Tienoven… in British Journal of Cancer (1999)

Article

Expression of class I and class II HLA antigens in primary and metastatic melanoma: Relation to prognosis

E. B. Bröcker, D. J. Ruiter, L. Suter in Journal of Cancer Research and Clinical Oncology (1986)