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Article
Open AccessA mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma
A vestibular schwannoma (VS) is a relatively rare, benign tumour of the eighth cranial nerve, often involving alterations to the gene NF2. Previous mathematical models of schwannoma incidence have not attempted t...
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Article
BRCA1/2 in non-mucinous epithelial ovarian cancer: tumour with or without germline testing?
National guidelines recommend testing all cases of non-mucinous epithelial ovarian cancer (NMEOC) for germline (blood) and somatic (tumour) BRCA1/2 pathogenic variants (PVs). We performed paired germline and soma...
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Article
Open AccessBreast cancer risk feedback to women in the UK NHS breast screening population
There are widespread moves to develop risk-stratified approaches to population-based breast screening. The public needs to favour receiving breast cancer risk information, which ideally should produce no detri...