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Article
Open AccessThe role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy
When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide addi...
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Article
Open AccessBursting of excitatory cells is linked to interictal epileptic discharge generation in humans
Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interi...
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Article
Open AccessThe sleep EEG envelope is a novel, neuronal firing-based human biomarker
Sleep EEG reflects voltage differences relative to a reference, while its spectrum reflects its composition of various frequencies. In contrast, the envelope of the sleep EEG reflects the instantaneous amplitu...
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Article
Open AccessIntracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans
Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgic...
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Article
Open AccessDifferential cortical layer engagement during seizure initiation and spread in humans
Despite decades of research, we still do not understand how spontaneous human seizures start and spread – especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-elect...