24 Result(s)
within
Curtis Huttenhower
Microbiology
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Article
Challenges and opportunities in sharing microbiome data and analyses
Microbiome data, metadata and analytical workflows have become ‘big’ in terms of volume and complexity. Although the infrastructure and technologies to share data have been established, the interdisciplinary a...
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Article
Open AccessRNA-based amplicon sequencing is ineffective in measuring metabolic activity in environmental microbial communities
Characterization of microbial activity is essential to the understanding of the basic biology of microbial communities, as the function of a microbiome is defined by its biochemically active (“viable”) communi...
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Open AccessThe gut microbiome modifies the associations of short- and long-term physical activity with body weight changes
The gut microbiome regulates host energy balance and adiposity-related metabolic consequences, but it remains unknown how the gut microbiome modulates body weight response to physical activity (PA).
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A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria
Members of the human gut microbiome enzymatically process many bioactive molecules in the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic or reductive in nature. He...
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Open AccessDietary lignans, plasma enterolactone levels, and metabolic risk in men: exploring the role of the gut microbiome
The conversion of plant lignans to bioactive enterolignans in the gastrointestinal tract is mediated through microbial processing. The goal of this study was to examine the relationships between lignan intake,...
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Open AccessWhole microbial community viability is not quantitatively reflected by propidium monoazide sequencing approach
High-throughput sequencing provides a powerful window into the structural and functional profiling of microbial communities, but it is unable to characterize only the viable portion of microbial communities at...
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Growth effects of N-acylethanolamines on gut bacteria reflect altered bacterial abundances in inflammatory bowel disease
Inflammatory bowel diseases (IBD) are associated with alterations in gut microbial abundances and lumenal metabolite concentrations, but the effects of specific metabolites on the gut microbiota in health and ...
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Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease
In the Supplementary Tables 2, 4 and 6 originally published with this Article, the authors mistakenly included sample identifiers in the form of UMCGs rather than UMCG IBDs in the validation cohort; this has n...
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Publisher Correction: Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life
In the version of this Article originally published, in the first sentence of the second paragraph of the Discussion section, the word “operingrationally” should have read “operationally”. This has now been am...
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Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life
The human gut microbiome matures towards the adult composition during the first years of life and is implicated in early immune development. Here, we investigate the effects of microbial genomic diversity on g...
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Gut microbiome structure and metabolic activity in inflammatory bowel disease
The inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has been associated with d...
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Open AccessNext steps in studying the human microbiome and health in prospective studies, Bethesda, MD, May 16–17, 2017
The National Cancer Institute (NCI) sponsored a 2-day workshop, “Next Steps in Studying the Human Microbiome and Health in Prospective Studies,” in Bethesda, Maryland, May 16–17, 2017. The workshop brought tog...
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Open AccessDaylight exposure modulates bacterial communities associated with household dust
Microbial communities associated with indoor dust abound in the built environment. The transmission of sunlight through windows is a key building design consideration, but the effects of light exposure on dust...
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Publisher Correction: Enterotypes in the landscape of gut microbial community composition
In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective.
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Stability of the human faecal microbiome in a cohort of adult men
Characterizing the stability of the gut microbiome is important to exploit it as a therapeutic target and diagnostic biomarker. We metagenomically and metatranscriptomically sequenced the faecal microbiomes of...
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Metatranscriptome of human faecal microbial communities in a cohort of adult men
The gut microbiome is intimately related to human health, but it is not yet known which functional activities are driven by specific microorganisms' ecological configurations or transcription. We report a larg...
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Dynamics of metatranscription in the inflammatory bowel disease gut microbiome
Inflammatory bowel disease (IBD) is a group of chronic diseases of the digestive tract that affects millions of people worldwide. Genetic, environmental and microbial factors have been implicated in the onset ...
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Enterotypes in the landscape of gut microbial community composition
Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome...
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Open AccessSchrödinger’s microbes: Tools for distinguishing the living from the dead in microbial ecosystems
While often obvious for macroscopic organisms, determining whether a microbe is dead or alive is fraught with complications. Fields such as microbial ecology, environmental health, and medical microbiology eac...
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Uncovering oral Neisseria tropism and persistence using metagenomic sequencing
Microbial epidemiology and population genomics have previously been carried out near-exclusively for organisms grown in vitro. Metagenomics helps to overcome this limitation, but it is still challenging to achiev...
