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    Article

    Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine

    Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has been linked to depression pathology, changes in myelination may be a pivotal mechanism underlying ketamine’s long-last...

    Chaoli Huang, Zifeng Wu, Di Wang, Youge Qu, Jichun Zhang in Molecular Psychiatry (2023)

  2. Article

    Open Access

    Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety

    Pain and anxiety comorbidities are a common health problem, but the neural mechanisms underlying comorbidity remain unclear. We propose that comorbidity implies that similar brain regions and neural circuits, ...

    Di Wang, **angyu Pan, Yu Zhou, Zifeng Wu, Kunpeng Ren, Hanyu Liu in Molecular Psychiatry (2023)

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    Article

    Desulfovibrio confers resilience to the comorbidity of pain and anxiety in a mouse model of chronic inflammatory pain

    Patients with chronic pain frequently suffer from anxiety symptoms. It has been well established that gut microbiota is associated with the pathogenesis of pain and anxiety. However, it is unknown whether the ...

    Zifeng Wu, Hanyu Liu, Enshi Yan, **nying Zhang, Yuanyuan Wang in Psychopharmacology (2023)

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    Article

    PP2A-associated tau hyperphosphorylation was involved in sevoflurane induced neonatal neurotoxicity

    The effects of sevoflurane anesthesia on childhood neurodevelopment and adult brain function have attracted increasing scientific attentions. However, the exact mechanisms underlying hyperphosphorylation of ta...

    Chaoli Huang, Teng He, Di Wang, Zifeng Wu, Yuanyuan Wang, Hanyu Liu in Psychopharmacology (2022)

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    Article

    Pivotal role of the gut microbiota in congenital insensitivity to pain with anhidrosis

    Increasing evidence has shown that the occurrence and development of various human diseases are closely related to the gut microbiota. We compared the gut microbial communities of human subjects with congenita...

    Mi Zhang, Yishun Hong, Wenyao Wu, Ningbo Li, Baowen Liu, Jiaoli Sun in Psychopharmacology (2021)

  6. Article

    Open Access

    miR-98-5p plays a critical role in depression and antidepressant effect of ketamine

    Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent studies have emerged microRNAs as important modulators for dep...

    Chaoli Huang, Yuanyuan Wang, Zifeng Wu, Jiali Xu, Ling Zhou in Translational Psychiatry (2021)