-
Article
TGF-β1-Induced LINC01094 promotes epithelial-mesenchymal transition in hepatocellular carcinoma through the miR-122-5p/TGFBR2–SAMD2–SMAD3 Axis
Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. It has been proven that long non-coding RNAs (lncRNAs) play an essential role in regulating HCC progression. However, the involvemen...
-
Article
Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats
Synaptic dysfunction is considered the best neuropathological correlate of cognitive decline in vascular dementia (VaD). However, the alterations of synaptic proteins at the synaptosomal level in VaD remain un...
-
Article
Open AccessRapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer
Pancreatic cancer is one of the most lethal malignancies and the lack of treatment options makes it more deadly. Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has revolutionized cancer treatment and m...
-
Article
Open AccessMolecular alterations and prognosis of breast cancer with cutaneous metastasis
Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment and poor prognosis. A better understanding of the molecular alterations involved ...
-
Article
Carbon Abatement and Socio-environmental Impacts Oriented to Government Policies and Corporate Social Responsibility
Under the constraint of considering corporate social responsibility (CSR), companies have to consider the impact of corporate social responsibility on their production operations and carbon abatement decisions...
-
Article
An improved tracking differentiator based on discrete-time optimal control and its application for electromagnet suspension control in active vibration isolation system
The differentiator is one way to extract the derivative of the signal. However, it is challenging to achieve both accuracy and robustness in the differentiator design when the input signal is subject to noise....
-
Article
Open AccessTranscriptomic analysis reveals the regulatory mechanisms of messenger RNA (mRNA) and long non-coding RNA (lncRNA) in response to waterlogging stress in rye (Secale cereale L.)
Waterlogging stress (WS) negatively impacts crop growth and productivity, making it important to understand crop resistance processes and discover useful WS resistance genes. In this study, rye cultivars and w...
-
Article
Open AccessBATF promotes tumor progression and association with FDG PET-derived parameters in colorectal cancer
The purpose of the study was to evaluate the expression and function of basic leucine zipper ATF-like transcription factor (BATF) in colorectal cancer (CRC), and its correlation with 2-deoxy-2[18F]fluoro-d-glucos...
-
Article
Open AccessFTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older...
-
Article
Anxiety, depression and sleep problems in PCI patients: a cross-lag panel analysis
In recent years, Percutaneous Coronary Intervention (PCI) has been the method of choice for blood flow reconstruction in cardiovascular disease patients. Patients with undergoing CVD interventional therapy oft...
-
Article
Open AccessPrevalence and associated factors of excessive daytime sleepiness in rural older adults: a population-based study
To investigate the prevalence and associated factors of excessive daytime sleepiness (EDS) among rural-dwelling Chinese older adults.
-
Article
Effect of Electron Structure of La-Based Perovskites on the Catalytic Combustion of n-Butylamine
Studying the relationship between electronic structure and activity helps to understand the catalytic mechanism since the catalytic combustion is a redox reaction dominated by electron transfer. Herein, we reg...
-
Article
Tri-band electrochromic smart window for energy savings in buildings
Electrochromic windows provide a sustainable solution for use in energy-efficient buildings as their varying optical properties in changing weather conditions allow the optimization of solar radiation heat gai...
-
Article
Projections of summer light rain frequency in typical terrain over eastern China under wind speed constraint
The variation in near-surface wind speed is a key dynamic parameter in the orographic effect of precipitation over eastern China. In this study, we used the latest high-resolution outputs from six GCMs in CMIP...
-
Article
School Acceptance and Support Moderate the Relationship Between Parental Divorce and Adolescents’ Prosocial Behavior: A Longitudinal Study
The nurturing of offspring within divorced families has consistently been a matter of concern. Parental divorce is a pivotal environmental determinant influencing the progression of adolescents’ prosocial beha...
-
Article
Iron Overload–Dependent Ferroptosis Aggravates LPS-Induced Acute Lung Injury by Impairing Mitochondrial Function
Ferroptosis is a newly proposed form of programmed cell death that is iron-dependent and closely linked to oxidative stress. Its specific morphological changes include shrunken mitochondria, increased density ...
-
Article
Lycopene promoted M2 macrophage polarization via inhibition of NOTCH1-PI3K-mTOR-NF-κB-JMJD3-IRF4 pathway in response to Escherichia coli infection in J744A.1 cells
Escherichia coli (E. coli) can induce severe clinical bovine mastitis, which is to blame for large losses experienced by dairy farms. Macrophage polarization into various states is in response to pathogen infecti...
-
Article
Genetically optimizing soybean nodulation improves yield and protein content
Symbiotic nitrogen fixation in legume nodules requires substantial energy investment from host plants, and soybean (Glycine max (L.) supernodulation mutants show stunting and yield penalties due to overconsumptio...
-
Article
Term energies and radiative atomic data of carbon-like ions Na VI and Al VIII
Excitation energies belonging to the (1s2)2s22p2, 2s22p3p, 2s2p3, 2s22p3s, and 2s22p3d configurations of carbon-like Na VI and Al VIII have been calculated with the multi-configuration Rayleigh–Ritz variation met...
-
Article
Open AccessMETTL3-mediated deficiency of lncRNA HAR1A drives non-small cell lung cancer growth and metastasis by promoting ANXA2 stabilization
We previously reported lncRNA HAR1A as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the delicate working mechanisms of this lncRNA remain obscure. Herein, we demonstrated that the ectopic ex...
