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IMPAIRED IMMUNE RECONSTITUTION POST SEQUENTIAL HIGH-DOSE CHEMOTHERAPY AND PERIPHERAL BLOOD PROGENITOR CELL (PBPC) INFUSION. † 962
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SKEWING OF THE T CELL REPERTOIRE TOWARD A TARGET ANTIGEN DURING A PERIOD OF T CELL IMMUNE RECONSTITUTION. • 935
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Langerhans Cells in the TGFβ1 Null Mouse
We recently identified a cell surface protein (gp40) that is homologous to human EpCAM, a putative homophilic adhesion molecule, and that is abundantly expressed by some murine dendritic cells (including Lang...
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Current concepts of thymic aging
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Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
CD4+CD25+ regulatory T (Treg) cells have a crucial role in maintaining immune tolerance. Mice and humans born lacking Treg cells develop severe autoimmune disease1,2, and depletion of Treg cells in lymphopenic mi...
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Article
Immune reconstitution prevents metastatic recurrence of murine osteosarcoma
Primary tumors develo** in immunocompetent hosts escape immunosurveillance by acquiring immune evasive properties. This raises the prospect that metastases derived from such tumors will also evade immunity. ...
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Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation
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Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
Compared with naive CD8+ T cells, naive CD4+ T cells undergo inefficient homeostatic proliferation. Mackall and colleagues now attribute this difference to interleukin 7–mediated suppression of the expression of ...
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Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches
Dendritic cells (DCs) serve as central regulators of adaptive immunity by presenting antigens and providing necessary co-signals. Environmental information received by the DCs determines the co-signals deliver...
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Reply to “Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells?”
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Harnessing the biology of IL-7 for therapeutic application
Interleukin-7 (IL-7) is required for T cell development in mice and humans and is produced by stromal tissues rather than activated lymphocytes. Under normal c...
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Article
Open AccessEnhanced glycolytic metabolism is associated with exhaustion and poor antitumor efficacy in a xenograft model of chimeric antigen receptor T cell therapy for sarcoma
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Open AccessALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors
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Open AccessNeutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors
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Immune-based therapies for childhood cancer
Graft-versus-leukaemic effects improve survival following allogeneic stem cell transplantation for childhood leukaemia, and provide proof-of-principle that imm...
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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
Crystal Mackall and colleagues report that antigen-independent signaling of chimeric antigen receptors (CARs) causes T cell exhaustion and reduced therapeutic efficacy of CAR T cells that can be overcome by in...
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Chimeric Antigen Receptors for Cancer: Progress and Challenges
Chimeric antigen receptors (CARs) genetically link an antigen-binding domain with cell-signaling domains to redirect immune cell specificity toward antigens expressed on the surface of cancer cells. Progress i...
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Open AccessCD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL)....
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Neuroblastoma
Neuroblastoma is the most common extracranial solid tumour occurring in childhood and has a diverse clinical presentation and course depending on the tumour biology. Unique features of these neuroendocrine tum...
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Open AccessElutriated lymphocytes for manufacturing chimeric antigen receptor T cells
Clinical trials of Chimeric Antigen Receptor (CAR) T cells manufactured from autologous peripheral blood mononuclear cell (PBMC) concentrates for the treatment of hematologic malignancies have been promising, ...
