14 Result(s)
within
Crystal L. Mackall
Immunology
-
Article
Open AccessSystemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma
Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794),...
-
Article
CAR T cell therapy: inroads to response and resistance
Here, we highlight key papers published in 2018 that advance our understanding of resistance to chimeric antigen receptor (CAR) T cell immunotherapy for leukaemia and lymphoma and in so doing reveal barriers t...
-
Article
Open AccessChimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance
Chimeric Antigen Receptor (CAR) T cell therapies – adoptive T cell therapies that have been genetically engineered for a new antigen-specificity - have displayed significant success in treating patients with h...
-
Article
Chimeric Antigen Receptors for Cancer: Progress and Challenges
Chimeric antigen receptors (CARs) genetically link an antigen-binding domain with cell-signaling domains to redirect immune cell specificity toward antigens expressed on the surface of cancer cells. Progress i...
-
Article
Open AccessEnhanced glycolytic metabolism is associated with exhaustion and poor antitumor efficacy in a xenograft model of chimeric antigen receptor T cell therapy for sarcoma
-
Article
Open AccessALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors
-
Article
Open AccessNeutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors
-
Article
Harnessing the biology of IL-7 for therapeutic application
Interleukin-7 (IL-7) is required for T cell development in mice and humans and is produced by stromal tissues rather than activated lymphocytes. Under normal c...
-
Article
Reply to “Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells?”
-
Article
Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches
Dendritic cells (DCs) serve as central regulators of adaptive immunity by presenting antigens and providing necessary co-signals. Environmental information received by the DCs determines the co-signals deliver...
-
Article
Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
Compared with naive CD8+ T cells, naive CD4+ T cells undergo inefficient homeostatic proliferation. Mackall and colleagues now attribute this difference to interleukin 7–mediated suppression of the expression of ...
-
Article
Immune reconstitution prevents metastatic recurrence of murine osteosarcoma
Primary tumors develo** in immunocompetent hosts escape immunosurveillance by acquiring immune evasive properties. This raises the prospect that metastases derived from such tumors will also evade immunity. ...
-
Article
Current concepts of thymic aging
-
Chapter
Langerhans Cells in the TGFβ1 Null Mouse
We recently identified a cell surface protein (gp40) that is homologous to human EpCAM, a putative homophilic adhesion molecule, and that is abundantly expressed by some murine dendritic cells (including Lang...
