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Enhancing pediatric access to cell and gene therapies

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  1. Article

    Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

    Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen receptor (CAR) T cell therapies targeting CD19 experience disease progression, and neurotoxicity remains a challenge. Biom...

    Zinaida Good, Jay Y. Spiegel, Bita Sahaf, Meena B. Malipatlolla… in Nature Medicine (2022)

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  2. Article

    Open Access

    CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

    Despite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL)...

    Jay Y. Spiegel, Shabnum Patel, Lori Muffly, Nasheed M. Hossain, Jean Oak… in Nature Medicine (2021)

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