46 Result(s)

Article

Biodistribution and radiation dosimetry of [^99mTc]Tc-N4-BTG in patients with biochemical recurrence of prostate cancer

In patients with prostate cancer (PCa), imaging with gastrin-releasing peptide receptor (GRPR) ligands is an alternative to PSMA-targeted tracers, particularly if PSMA expression is low or absent. [^99mTc]Tc-N4-BT...

Andreas Rinscheid, Alexander Gäble, Georgine Wienand, Alexander Dierks… in EJNMMI Research (2024)

Article

Intense PSMA expression of the uvula detected by [⁶⁸ Ga]Ga-PSMA-PET/CT

Lisa Glantschnig, Alexander Dierks… in European Journal of Nuclear Medicine and M… (2024)

Article

CXCR4-directed PET/CT with [⁶⁸ Ga]Ga-pentixafor in solid tumors—a comprehensive analysis of imaging findings and comparison with histopathology

C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in various solid cancers and can be targeted by CXCR4-directed molecular imaging. We aimed to characterize the in-vivo CXCR4 expression in patients aff...

Niklas Dreher, Stefanie Hahner… in European Journal of Nuclear Medicine and M… (2024)

Article

Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs

We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)₈-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH₂), that revealed substantially increased activity retention in t...

Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam… in EJNMMI Research (2024)

Article

Comparison of PET/CT-based eligibility according to VISION and TheraP trial criteria in end-stage prostate cancer patients undergoing radioligand therapy

Two randomized clinical trials demonstrated the efficacy of prostate-specific membrane antigen (PSMA) radioligand therapy (PSMA RLT) in metastatic castration-resistant prostate cancer (mCRPC). While the VISION...

Kerstin Michalski, Aleksander Kosmala, Rudolf A. Werner… in Annals of Nuclear Medicine (2024)

Article

Chemokine receptor–targeted PET/CT provides superior diagnostic performance in newly diagnosed marginal zone lymphoma patients: a head-to-head comparison with [¹⁸F]FDG

In patients with marginal zone lymphoma (MZL), [¹⁸F]FDG PET/CT provided inconsistent diagnostic accuracy. C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in MZL and thus, may emerge as novel theranostic...

Aleksander Kosmala, Johannes Duell… in European Journal of Nuclear Medicine and M… (2024)

Article

[^99mTc]Tc-PentixaTec: development, extensive pre-clinical evaluation, and first human experience

The clinical success non-invasive imaging of CXCR4 expression using [⁶⁸ Ga]Ga-PentixaFor-PET warrants an expansion of the targeting concept towards conventional scintigraphy/SPECT with their lower cost and genera...

Matthias Konrad, Andreas Rinscheid… in European Journal of Nuclear Medicine and M… (2023)

Article

Early biochemical and radiographic response after one cycle of [¹⁷⁷Lu]Lu-PSMA I&T radioligand therapy in metastatic castration-resistant prostate cancer patients

The aim of this study was to investigate very early radiographic PSMA PET response after one cycle of [¹⁷⁷Lu]Lu-PSMA I&T radioligand therapy (RLT) of metastatic castration-resistant prostate cancer (mCRPC) and to...

Wojciech Cytawa, Robin Hendel… in European Journal of Nuclear Medicine and M… (2023)

Article

Granulomatous dermatitis: a rare pitfall in lymphoma staging with [¹⁸F]FDG-PET/CT

Johanna S. Enke, Alexander Gäble… in European Journal of Nuclear Medicine and M… (2023)

Article

Sarcoidosis mimicking nodal manifestations of marginal zone lymphoma

Johanna S. Enke, Nic G. Reitsam… in European Journal of Nuclear Medicine and M… (2023)

Article

Investigation of the structure-activity relationship at the N-terminal part of minigastrin analogs

Over the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently applied compounds still reveal limited in vitro and in vivo stability. W...

Nadine Holzleitner, Thomas Günther, Amira Daoud-Gadieh, Constantin Lapa… in EJNMMI Research (2023)

Article

[¹⁸F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making?

Positron emission tomography (PET) with O-(2-[¹⁸F]fluoroethyl)-L-tyrosine ([¹⁸F]FET) is a well-established tool for non-invasive assessment of adult central nervous system (CNS) tumors. However, data on its diagn...

Olivia Kertels, Jürgen Krauß… in European Journal of Nuclear Medicine and M… (2023)

Article

Convolutional neural networks for automatic image quality control and EARL compliance of PET images

Machine learning studies require a large number of images often obtained on different PET scanners. When merging these images, the use of harmonized images following EARL-standards is essential. However, when ...

Elisabeth Pfaehler, Daniela Euba, Andreas Rinscheid, Otto S. Hoekstra… in EJNMMI Physics (2022)

Article

Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity – initial experience and comparison to [¹⁸F]FDG PET/CT and MRI

While [¹⁸F]-fluorodeoxyglucose ([¹⁸F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity is hampered by uptake...

Christian Linz, Roman C. Brands… in European Journal of Nuclear Medicine and M… (2021)

Article

Investigation of spleen CXCR4 expression by [⁶⁸Ga]Pentixafor PET in a cohort of 145 solid cancer patients

The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter… in EJNMMI Research (2021)

Article

Intraindividual comparison of [¹⁷⁷Lu]Lu-DOTA-EB-TATE and [¹⁷⁷Lu]Lu-DOTA-TOC

The radiolabelled somatostatin analogue [¹⁷⁷Lu]Lu-DOTA-EB-TATE binds to albumin via Evans blue, thereby increasing the residence time in the blood and potentially allowing more therapeutic agent to be absorbed in...

Heribert Hänscheid, Philipp E. Hartrampf… in European Journal of Nuclear Medicine and M… (2021)

Article

Prognostic implications of dual tracer PET/CT: PSMA ligand and [¹⁸F]FDG PET/CT in patients undergoing [¹⁷⁷Lu]PSMA radioligand therapy

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) with ¹⁷⁷Lu-labeled PSMA ligands has achieved remarkable results in advanced disease stages of metastatic castration-resistant prostate ...

Kerstin Michalski, Juri Ruf, Christian Goetz… in European Journal of Nuclear Medicine and M… (2021)

Article

Sarcoid-like reactions: a potential pitfall in oncologic imaging

Selamawit Gebrekidan, Tina Schaller… in European Journal of Nuclear Medicine and M… (2021)

Article

Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging

Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These syst...

Jan V. Hoffmann, Jan P. Janssen, Takayuki Kanno, Takayuki Shibutani… in EJNMMI Physics (2020)