8 Result(s)

Article

Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid ar...

Esteban A. Gomez, Romain A. Colas, Patricia R. Souza… in Nature Communications (2020)

Article

Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer

Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successful treatment for select women. Ho...

Emanuela Gadaleta, Pauline Fourgoux, Stefano Pirró, Graeme J. Thorn… in npj Breast Cancer (2020)

Article

Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti

Aedes aegypti is a vector for the (re-)emerging human pathogens dengue, chikungunya, yellow fever and Zika viruses. Almost half of the Ae. aegypti genome is comprised of transposable e...

Kevin Maringer, Amjad Yousuf, Kate J. Heesom, Jun Fan, David Lee… in BMC Genomics (2017)

Article

Novel application of heuristic optimisation enables the creation and thorough evaluation of robust support vector machine ensembles for machine learning applications

Today’s researchers have access to an unprecedented range of powerful machine learning tools with which to build models for classifying samples according to their metabolomic profile (e.g. separating diseased ...

Eleni Anthippi Chatzimichali, Conrad Bessant in Metabolomics (2015)

Article

OSPACS: Ultrasound image management system

Ultrasound scanning uses the medical imaging format, DICOM, for electronically storing the images and data associated with a particular scan. Large health care facilities typically use a picture archiving and ...

Will Stott, Andy Ryan, Ian J Jacobs, Usha Menon… in Source Code for Biology and Medicine (2008)

Article

Proposed minimum reporting standards for data analysis in metabolomics

The goal of this group is to define the reporting requirements associated with the statistical analysis (including univariate, multivariate, informatics, machine learning etc.) of metabolite data with respect ...

Royston Goodacre, David Broadhurst, Age K. Smilde, Bruce S. Kristal… in Metabolomics (2007)

Article

Gene regulatory network of human adipocyte differentiation

Judit Kumuthini, Conrad Bessant, Paul Wilson, Daniel Crowther in BMC Systems Biology (2007)

Article

i-Tracker: For quantitative proteomics using iTRAQ™

iTRAQ™ technology for protein quantitation using mass spectrometry is a recent, powerful means of determining relative protein levels in up to four samples simultaneously. Although protein identification of sa...

Ian P Shadforth, Tom PJ Dunkley, Kathryn S Lilley, Conrad Bessant in BMC Genomics (2005)