9 Result(s)

Article

PRDM14 extinction enables the initiation of trophoblast stem cell formation

Trophoblast stem cells (TSCs) can be chemically converted from embryonic stem cells (ESCs) in vitro. Although several transcription factors (TFs) have been recognized as essential for TSC formation, it remains...

Chunfang Xu, Weijie Zhao, Li** Peng, Tingxuan Yin… in Cellular and Molecular Life Sciences (2024)

Article

Establishment and characterization of a novel cell line (SCCOHT-CH-1) and PDX models derived from Chinese patients of small cell ovarian carcinoma of the hypercalcemic type

Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare and aggressive malignancy that poses a significant clinical challenge due to its grim prognosis. Unfortunately, only three SCCOHT cell li...

Yi Gao, Kewei Zheng, Mingyi Kang, **g Xu, Yan Ning, Weiguo Hu, Ke Li… in Human Cell (2023)

Article

Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening

Current non-invasive prenatal screening (NIPS) analyzes circulating fetal cell-free DNA (cfDNA) in maternal peripheral blood for selected aneuploidies or microdeletion/duplication syndromes. Many genetic disor...

Chenming Xu, Jianli Li, Songchang Chen, **aoqiang Cai, Ruilin **g… in Cell Discovery (2022)

Article

ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway

Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently re...

Yubin Feng, **aoxiao Hua, Ruowen Niu, Yan Du, Congjian Shi… in Biological Research (2019)

Article

Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer

Sialyltransferases transfer sialic acid to nascent oligosaccharides and are upregulated in cancer. The inhibition of sialyltransferases is emerging as a potential strategy to prevent metastasis in several canc...

**n Wu, Junda Zhao, Yuanyuan Ruan, Li Sun, Congjian Xu, Hua Jiang in Cell Death & Disease (2018)

Article

Lectin array and glycogene expression analyses of ovarian cancer cell line A2780 and its cisplatin-resistant derivate cell line A2780-cp

Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance is a common cause of its relapse and death. Glycosylation has been reported to be involved in drug resistance, ...

Ran Zhao, Wenjun Qin, Ruihuan Qin, **g Han, Can Li, Yisheng Wang… in Clinical Proteomics (2017)

Article

Integrated glycomic analysis of ovarian cancer side population cells

Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulat...

Ran Zhao, **aoxia Liu, Yisheng Wang, **aoxiang Jie, Ruihuan Qin… in Clinical Proteomics (2016)

Article

Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types

Shifang Ren, Zejian Zhang, Congjian Xu, Lin Guo, Renquan Lu, Yihong Sun… in Cell Research (2016)

Article

Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes

Human papillomaviruses (HPVs) including high-risk (HR) and low-risk (LR) subtypes have distinguishable variation on both genotypes and phenotypes. The co-infection of multiple HR-HPVs, headed by HPV16, is comm...

Lin Lin, Qingqing Cai, **aoyan Zhang, Hongwei Zhang, Yang Zhong… in Protein & Cell (2015)