5 Result(s)
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Article
Open AccessTargeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex
Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergisticall...
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Article
Open AccessAbiraterone induces SLCO1B3 expression in prostate cancer via microRNA-579-3p
Understanding mechanisms of resistance to abiraterone, one of the primary drugs approved for the treatment of castration resistant prostate cancer, remains a priority. The organic anion polypeptide 1B3 (OATP1B...
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Article
Open AccessPilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers
OATP1B3 is expressed de novo in primary prostate cancer tissue and to a greater degree in prostate cancer metastases. Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate w...
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Article
Open AccessCereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide
Carfilzomib-lenalidomide-dexamethasone (KRd) therapy has yielded promising results in patients with newly diagnosed multiple myeloma (NDMM). Cereblon (CRBN) is the direct molecular target of lenalidomide and g...
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Article
Open AccessShared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model
Angiogenesis, the formation of new blood vessels, is essential for tumor growth, stabilization and progression. Angiogenesis inhibitors are now widely used in the clinic; however, there are relatively few publ...
