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Article
Genetic analysis of litchi (Litchi chinensis Sonn.) in southern China by improved random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR)
Litchi (Litchi chinensis Sonn., L. chinensis), a type of tree growing in most areas of southern China, produces an edible fruit that is also a source of traditional medicine. Genetic identification of litchi spec...
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Article
Open AccessEstablishment of Stable Cell Line for Inducing Kap1 Protein Expression
Generation of the stable cell lines is a highly efficient tool in functional studies of certain genes or proteins, where the particular genes or proteins are inducibly expressed. The KRAB-associated protein-1 ...
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Article
Open AccessPrognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis
The epithelial-to-mesenchymal transition (EMT) is a vital control point in metastatic breast cancer (MBC). TWIST1, SNAIL1, SLUG, and ZEB1, as key EMT-inducing transcription factors (EMT-TFs), are involved in M...
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Article
Open AccessTripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein
TRIM28 regulates its target genes at both transcriptional and posttranscriptional levels. Here we report that a TRIM28-TWIST1-EMT axis exists in breast cancer cells and TRIM28 promotes breast cancer metastasis...
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Article
Open AccessGender Differences in Behavioral and Neural Responses to Unfairness Under Social Pressure
Numerous studies have revealed the key role of social pressure on individuals’ decision-making processes. However, the impact of social pressure on unfairness-related decision-making processes remains unclear....
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Article
Open AccessA novel homozygous variant of GPR98 causes usher syndrome type IIC in a consanguineous Chinese family by next generation sequencing
Usher syndrome (USH) is a common heterogeneous retinopathy and a hearing loss (HL) syndrome. However, the gene causing Usher syndrome type IIC (USH2C) in a consanguineous Chinese pedigree is unknown.
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Article
Evaluation genotypes of cancer cell lines HCC1954 and SiHa by short tandem repeat (STR) analysis and DNA sequencing
Cancer cell lines are used worldwide in biomedical researches, and data interpretation solely depends on unambiguous attribution of those respective cell lines to its original sources. Approximately one-third ...
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Article
Characterization and molecular cloning of novel isoforms of human spermatogenesis associated gene SPATA3
This study aimed to clone and characterize novel isoforms of the human SPATA3 gene. The isoforms of SPATA3 gene was cloned into pGMT vector using human testis cDNA as template, and Sanger sequencing was performed...
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Article
Correction to: Characterization and molecular cloning of novel isoforms of human spermatogenesis associated gene SPATA3
Unfortunately, as for the second institute name of first author Baixu Zhou, “Department of Gynecology and Obstetrics, Guangzhou Women and Children’s Hospital, Guangzhou, Guangdong, China”, should be “Departmen...
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Article
Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19
The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances for this gene in ...
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Article
SCAR marker for identification and discrimination of specific medicinal Lycium chinense Miller from Lycium species from ramp-PCR RAPD fragments
In the current study, ramp-PCR fragments from improved RAPD (random amplified polymorphic DNA) amplification of Lycium (Goji) species or cultivars were cut and cloned into the vector of pGEM-T. A positive clone 1...
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Article
Assessing 23 Y-STR loci mutation rates in Chinese Han father–son pairs from southwestern China
In this study, we have analyzed 23 Y-chromosomal short tandem repeats (Y-STRs) (DYS576, DYS389I, DYS389II, DYS448, DYS19, DYS391, DYS481, DYS549, DYS533, DYS438, DYS437, DYS570, DYS635, DYS390, DYS439, DYS392,...
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Article
Open AccessEpigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis
RNF40 (OMIM: 607700) is a really interesting new gene (RING) finger E3 ubiquitin ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which engage in protein–DNA and protein–prote...
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Article
Novel compound heterozygous missense variants (c.G955A and c.A1822C) of CACNA2D4 likely causing autosomal recessive retinitis pigmentosa in a Chinese patient
Retinitis pigmentosa (RP) is a rare and heterogeneous group of inherited ocular diseases. However, the relationship between CACNA2D4 mutations and RP is not well understood. In this study, a Chinese autosomal rec...
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Article
Open AccessThe speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1
Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, speckle-type POZ protein (SPOP), regulates TWIST1 in b...
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Article
What does open peer review bring to scientific articles? Evidence from PLoS journals
This study examined the impact of open peer review (OPR) on the usage and citations of scientific articles using a dataset of 6441 articles published in six Public Library of Science (PLoS) journals in 2020–20...
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Article
Is the research performance of Chinese returnees better than that of their local counterparts?
Over the past few decades, the Chinese government has issued several policies to attract overseas elites to return to China and has given them privileges in academic resource allocation. This particular treatm...
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Article
In vitro and in vivo activity of ceftazidime/avibactam and aztreonam alone or in combination against mcr-9, serine- and metallo-β-lactamases–co-producing carbapenem-resistant Enterobacter cloacae complex
Enterobacteriaceae carrying mcr-9, in particularly those also co-containing metallo-β-lactamase (MBL) and TEM type β-lactamase, present potential transmission risks and lack adequate clinical response methods, th...
