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Article
Open AccessTranscranial direct current stimulation–induced changes in motor cortical connectivity are associated with motor gains following ischemic stroke
Understanding the response of the injured brain to different transcranial direct current stimulation (tDCS) montages may help explain the variable tDCS treatment results on poststroke motor gains. Cortical con...
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Article
Open AccessA Bacillus velezensis strain isolated from oats with disease-preventing and growth-promoting properties
Endophytes have been shown to promote plant growth and health. In the present study, a Bacillus velezensis CH1 (CH1) strain was isolated and identified from high-quality oats, which was capable of producing indol...
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Article
Open AccessUnrecognized extensive charge of microbial gas in the Junggar basin
Different from the Qaidam basin with about 320 billion m3 microbial gas, only limited microbial gases were found from the Junggar basin with similarly abundant type III kerogen. To determine whether microbial gas...
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Article
Open AccessIntra-articular injection of miRNA-1 agomir, a novel chemically modified miRNA agonists alleviates osteoarthritis (OA) progression by downregulating Indian hedgehog in rats
Our objective in this study is to determine whether intra-articular injection of miRNA-1 can attenuate the progression of OA in rats by down regulating Ihh. Knee chondrocytes were isolated from male Sprague–Da...
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Article
Open AccessSEGCN: a subgraph encoding based graph convolutional network model for social bot detection
Message passing neural networks such as graph convolutional networks (GCN) can jointly consider various types of features for social bot detection. However, the expressive power of GCN is upper-bounded by the ...
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Article
Open AccessPI3K/Akt signaling pathway mediates the effect of low-dose boron on barrier function, proliferation and apoptosis in rat intestinal epithelial cells
Boron is an essential trace element with roles in growth, development, and physiological functions; however, its mechanism of action is still unclear. In this study, the regulatory roles of the PI3K/Akt signal...
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Article
Open AccessComprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors with unpredictable evolution and with a recurrence or metastasis rate of 10-40%. Current medical treatments for relapsed SFTs remain ineffective. Here...
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Article
Open AccessAssociation between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
The prevalence of high birth weight or large for gestational age (LGA) infants is increasing, with increasing evidence of pregnancy-related factors that may have long-term impacts on the health of the mother a...
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Article
Open AccessFrom comparative gene content and gene order to ancestral contigs, chromosomes and karyotypes
To reconstruct the ancestral genome of a set of phylogenetically related descendant species, we use the raccroche pipeline for organizing a large number of generalized gene adjacencies into contigs and then into ...
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Article
Open AccessScalable and switchable CO2-responsive membranes with high wettability for separation of various oil/water systems
Smart membranes with responsive wettability show promise for controllably separating oil/water mixtures, including immiscible oil-water mixtures and surfactant-stabilized oil/water emulsions. However, the memb...
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Article
Open AccessBioinformatics construction and experimental validation of a cuproptosis-related lncRNA prognostic model in lung adenocarcinoma for immunotherapy response prediction
Cuproptosis is a newly form of cell death. Cuproptosis related lncRNA in lung adenocarcinoma (LUAD) has also not been fully elucidated. In the present study, we aimed to construct a prognostic signature based ...
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Article
Open AccessDevelopment and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients
Lung Squamous Cell Carcinoma (LUSC) is an aggressive malignancy with limited therapeutic options. The response to immune therapy is a determining factor for the prognosis of LUSC patients. This study aimed to ...
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Article
Open AccessBiochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation
Xanthone-containing natural products display diverse pharmacological properties. The biosynthetic mechanisms of the xanthone formation have not been well documented. Here we show that the flavoprotein monooxyg...
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Article
Open AccessFlavin-enabled reductive and oxidative epoxide ring opening reactions
Epoxide ring opening reactions are common and important in both biological processes and synthetic applications and can be catalyzed in a non-redox manner by epoxide hydrolases or reductively by oxidoreductase...
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Article
Open AccessAuthor Correction: Association of adverse birth outcomes with in vitro fertilization after controlling infertility factors based on a singleton live birth cohort
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Open AccessAssociation of adverse birth outcomes with in vitro fertilization after controlling infertility factors based on a singleton live birth cohort
Infants conceived with in vitro fertilization (IVF) are exposed to underlying infertility and the IVF process. High risks of adverse birth outcomes (ABOs) were observed among these infants, including preterm b...
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Article
Open AccessCo-functioning of 2AP precursor amino acids enhances 2-acetyl-1-pyrroline under salt stress in aromatic rice (Oryza sativa L.) cultivars
Aromatic rice (Oryza sativa) fetches a premium price due to the pleasant aroma. The major aroma compound 2-acetyl-1-pyrroline (2AP) has been found to be enhanced under stress. This condition can be considered to ...
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Article
Open AccessDiamondoids and thiadiamondoids generated from hydrothermal pyrolysis of crude oil and TSR experiments
Diamondoid compounds are widely used to reflect thermal maturation of high mature source rocks or oils and oil cracking extents. However, diamondoids and thiadiamondoids were demonstrated to have newly been ge...
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Article
Open AccessFabrication and evaluation of slow-release lignin-based avermectin nano-delivery system with UV-shielding property
Nanopesticide is one of the best pesticide formulation technologies to overcome the disadvantages of traditional pesticides, which has received great attention from the international community. Using high-spee...
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Open AccessAuthor Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite