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  1. Article

    C-reactive protein stimulates RAGE expression in human coronary artery endothelial cells in vitro via ROS generation and ERK/NF-κB activation

    The receptor for advanced glycation end-products (RAGE) plays an important role in development of atherosclerosis, and C-reactive protein (CRP) has been found to stimulate its expression in endothelial cells. ...

    Yun Zhong, Chuan-fang Cheng, Yi-zhi Luo, Chao-wei Tian in Acta Pharmacologica Sinica (2015)

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    Article

    Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway

    Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy. Previous evidence suggests that puera...

    Ning Hou, Yin Huang, Shao-ai Cai, Wen-chang Yuan, Li-rong Li in Acta Pharmacologica Sinica (2021)