7 Result(s)
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Article
Application of 16S rRNA metagenomics to analyze bacterial communities at a respiratory care centre in Taiwan
In this study, we applied a 16S ribosomal RNA (rRNA) metagenomics approach to survey inanimate hospital environments (IHEs) in a respiratory care center (RCC). A total of 16 samples, including 9 from medical d...
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Open AccessTranscriptome profiling in imipenem-selected Acinetobacter baumannii
Carbapenem-resistance in Acinetobacter baumannii has gradually become a global challenge. To identify the genes involved in carbapenem resistance in A. baumannii, the transcriptomic responses of the completely se...
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Article
Open AccessThe chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation
SUMOylation, as part of the epigenetic regulation of transcription, has been intensively studied in lower eukaryotes that contain only a single SUMO protein; however, the functions of SUMOylation during mammal...
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Open AccessWhole-genome sequencing and identification of Morganella morganii KT pathogenicity-related genes
The opportunistic enterobacterium, Morganella morganii, which can cause bacteraemia, is the ninth most prevalent cause of clinical infections in patients at Changhua Christian Hospital, Taiwan. The KT strain of M...
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Open AccessAn efficient RNA interference screening strategy for gene functional analysis
RNA interference (RNAi) is commonly applied in genome-scale gene functional screens. However, a one-on-one RNAi analysis that targets each gene is cost-ineffective and laborious. Previous studies have indicate...
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Article
Open AccessMetabolic classification of microbial genomes using functional probes
Microorganisms able to grow under artificial culture conditions comprise only a small proportion of the biosphere's total microbial community. Until recently, scientists have been unable to perform thorough an...
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Article
Open AccessFeature amplified voting algorithm for functional analysis of protein superfamily
Identifying the regions associated with protein function is a singularly important task in the post-genomic era. Biological studies often identify functional enzyme residues by amino acid sequences, particular...
