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Article
Open AccessQuantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities
HER2-positive (HER2+) metastatic breast cancer (mBC) is highly aggressive and a major threat to human health. Despite the significant improvement in patients’ prognosis given the drug development efforts during t...
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Article
Open AccessABA-mediated regulation of rice grain quality and seed dormancy via the NF-YB1-SLRL2-bHLH144 Module
Abscisic acid (ABA) plays a crucial role in promoting plant stress resistance and seed dormancy. However, how ABA regulates rice quality remains unclear. This study identifies a key transcription factor SLR1-l...
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Article
Open AccessSurrogate-assisted sine Phasmatodea population evolution algorithm applied to 3D coverage of mobile nodes
Deploying static wireless sensor nodes is prone to network coverage gaps, resulting in poor network coverage. In this paper, an attempt is made to improve the network coverage by moving the locations of the no...
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Article
Design of weak current measurement system and research on temperature impact
A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization chamber. This system incorporates a second-order low-pass filter circuit and the Kalman...
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Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Article
Preface: Heavy metal(loid)s at mining & metallurgical sites: Fate, risk and remediation
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Article
Effect of Electromagnetic Oscillation on Grain Structure of K477 Superalloy Turbine Guide Castings
The electromagnetic oscillation treatment was introduced to enhance the fine-grain quality of the Cr–Co–Mo K477 superalloy turbine guide castings, and the effect of electromagnetic oscillation on the microstru...
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Article
Open AccessComparison of three-dimensional heads-up system versus traditional microscopic system in medical education for vitreoretinal surgeries: a prospective study
To compare the value and efficiency of the three-dimensional (3D) heads-up surgical system and traditional microscopic (TM) system in teaching and learning vitreoretinal surgeries.
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Article
MdPRX34L, a class III peroxidase gene, activates the immune response in apple to the fungal pathogen Botryosphaeria dothidea
MdPRX34L enhanced resistance to Botryosphaeria dothidea by increasing salicylic acid (SA) and abscisic acid (ABA) content as well as the expression of related defense genes.
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Article
Open AccessIGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma
Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box (FOX) family, FOXC1, assumes significance in embryonic develo...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Article
The shape complexity of hydrogenic impurity state in the Ga1 − χAlχN semiconductor quantum well
This study investigates the shape complexity of hydrogenic impurity states in the Ga1 − χAlχN semiconductor quantum well for the first time. The shape complexity is calculated for a specific hydrogenic impurity s...
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Article
Open AccessThe heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy among primary liver cancers, with an increasing overall incidence and poor prognosis. The intertumoral and intratumoral heterogeneity ...
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Chapter and Conference Paper
Preprocessing and Application of Resistivity Logging After Casing Data
Resistivity Logging after Casing (RLAC) can measure formation resistivity in cased wells, which shows unique advantages in reservoir monitoring and residual oil and gas resource evaluation, however, the origin...
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Chapter and Conference Paper
Classifiers of Mandarin Alphabetical Words with Character-Alphabet Structure
Mandarin alphabetical words (MAWs) refer to the code-mixing of Romanized letters and characters such as X光 ‘X-ray’ in the Mandarin lexicon. Previous studies have mainly focused on MAWs’ formation but lacked em...
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Article
Atom-referenced and stabilized soliton microcomb
For the applications of the frequency comb in microresonators, it is essential to obtain a fully frequency-stabilized microcomb laser source. In this study, we present a system for generating a fully atom-refe...
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Article
The automation software of Tian-Ma radio telescope RFI monitoring system
The Radio Frequency Interference (RFI) generated by the surrounding environment will significantly reduce the observation efficiency of the large radio telescope. The Tian-Ma Radio Telescope (TMRT) has establi...
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Article
Open AccessRegulation of a vacuolar proton-pum** P-ATPase MdPH5 by MdMYB73 and its role in malate accumulation and vacuolar acidification
As the main organic acid in fruits, malate is produced in the cytoplasm and is then transported into the vacuole. It accumulates by vacuolar proton pumps, transporters, and channels, affecting the taste and fl...
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Article
Open AccessOnline decision tools for personalized survival prediction and treatment optimization in elderly patients with lung squamous cell carcinoma: a retrospective cohort study
Despite major advances in cancer therapeutics, the therapeutic options of Lung Squamous Cell Carcinoma (LSCC)-specific remain limited. Furthermore, the current staging system is imperfect for defining a progno...
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Article
Open AccessThe correlation of two bone turnover markers with bone mineral density: a population-based cross-sectional study
Exploring the correlation between bone turnover marks (BTMs) with lumbar BMD in middle-aged populations.
