50 Result(s)

Article

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10⁻⁸) from the largest single-stage blood pressure (BP...

Jacob M. Keaton, Zoha Kamali, Tian **e, Ahmad Vaez, Ariel Williams… in Nature Genetics (2024)

Article

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell… in Nature (2022)

Article

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are ...

William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong… in Nature Communications (2022)

Article

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00832-z.

Praveen Surendran, Elena V. Feofanova, Najim Lahrouchi, Ioanna Ntalla… in Nature Genetics (2021)

Article

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) hav...

Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin… in Nature Communications (2020)

Article

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena… in Nature Genetics (2018)

Article

Genome-wide analysis yields new loci associating with aortic valve stenosis

Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS ca...

Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir… in Nature Communications (2018)

Article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

G. Todd Milne, Peter Sandner, Kathleen A. Lincoln… in BMC Pharmacology and Toxicology (2017)

Article

Correction: Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Nat. Genet.; doi:10.1038/ng.3768; corrected online 20 February 2017 In the version of this article initially published online, the name of Chiara Batini was misspelled as Chiara Battini in the list of collabor...

Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao… in Nature Genetics (2017)

Article

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Nat. Genet.; 10.1038/ng.3843; corrected online 11 May 2017 In the version of this article initially published online, the authors were incorrectly defined as members of the AFGen consortium in the author list....

Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, **aoyan Yin… in Nature Genetics (2017)