8 Result(s)
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Article
Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial
HIVACAT T-cell immunogen (HTI) is a novel human immunodeficiency virus (HIV) vaccine immunogen designed to elicit cellular immune responses to HIV targets associated with viral control in humans. The AELIX-002...
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Article
Small steps forward for HIV vaccine development
A trial of a therapeutic vaccine against HIV induces cellular immunity and, although it provides hope, it highlights the hurdles for the development of such strategies.
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Article
Open AccessVariants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection
The genetic bases of natural resistance to HIV-1 infection remain largely unknown. Recently, two genome-wide association studies suggested a role for variants within or in the vicinity of the CYP7B1 gene in modul...
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Article
HIV-1 over time: fitness loss or robustness gain?
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Article
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely empirical. To define the relationship, at the population level, between the specificity of the cellular immune resp...
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Article
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant responses in h...
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Article
Gradual adaptation of HIV to human host populations: good or bad news?
The continuous evolution and adaptation of HIV to its host has produced extensive global viral diversity. Understanding the kinetics and directions of this continuing adaptation and its impact on viral fitness...
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Article
Cytotoxic HIV-1 p55gag-Specific CD4+ T Cells Produce HIV-Inhibitory Cytokines and Chemokines
CD4+ T-helper cells appear to be essential in sustaining immune responses in chronic viral infections, as the maintenance of CD8+ cytotoxic T-lymphocyte responses and the control of viremia were demonstrated to d...
