6 Result(s)
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Christian Benner
Agriculture
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Article
Open AccessGenome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and...
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Article
Author Correction: Genetics of 35 blood and urine biomarkers in the UK Biobank
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Article
Computationally efficient whole-genome regression for quantitative and binary traits
Genome-wide association analysis of cohorts with thousands of phenotypes is computationally expensive, particularly when accounting for sample relatedness or population structure. Here we present a novel machi...
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Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 individuals). We identify 5,...
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Functionally informed fine-map** and polygenic localization of complex trait heritability
Fine-map** aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-map** accuracy by leveraging functional annotations across the...
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Article
Interrogation of human hematopoiesis at single-cell and single-variant resolution
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation represent substantial challenges to elucidating mechanisms of trait-associated genetic variation. Here we perform gen...
