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  1. No Access

    Article

    Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth

    Double-stranded RNA (dsRNA) can mediate its therapeutic effect through Toll-like receptor 3 (TLR3) expressed on tumor cells including neuroblastoma. We used synthetic dsRNA polyinosinic-polycytidylic acid [Pol...

    Jiin-Haur Chuang, Tsu-Kung Lin, Ming-Hong Tai, Chia-Wei Liou, Sheng-Teng Huang… in Apoptosis (2012)

  2. Article

    Open Access

    Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice

    Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) have shown promise in treating Duchenne muscular dystrophy (DMD). We evaluated a semi-mechanistic pharmacokinetic (PK) and pharmacodynamic (PD...

    Marie Claire Mukashyaka, Chia-Ling Wu, Kristin Ha, Jianbo Zhang… in Pharmaceutical Research (2021)

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  3. No Access

    Article

    Deep learning to design nuclear-targeting abiotic miniproteins

    There are more amino acid permutations within a 40-residue sequence than atoms on Earth. This vast chemical search space hinders the use of human learning to design functional polymers. Here we show how machin...

    Carly K. Schissel, Somesh Mohapatra, Justin M. Wolfe, Colin M. Fadzen… in Nature Chemistry (2021)

  4. No Access

    Article

    Prognostic Effects of Liver Fibrosis and Steatosis Determined Using Transient Elastography in Patients with Chronic Hepatitis B or C

    The prognostic effects of liver fibrosis and steatosis in patients with chronic hepatitis B or C are unclear. We investigated the prognostic effects of liver fibrosis and steatosis determined through transient...

    Chun-Li Wang, Chien-Hao Huang, Victor Chien-Chia Wu… in Digestive Diseases and Sciences (2023)