9 Result(s)
within
Chen-ling **ong
Biomedicine
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Article
Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice
Diabetic patients frequently experience neuropathic pain, which currently lacks effective treatments. The mechanisms underlying diabetic neuropathic pain remain unclear. The anterior cingulate cortex (ACC) is ...
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Article
Open AccessMelatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease
Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease (AD). Melatonin has been shown to prevent tau hy...
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Article
Open AccessCharacterization of a rare mosaic X-ring chromosome in a patient with Turner syndrome
Ring chromosomes can be formed by terminal breaks of two arms of a chromosome and their rejoining, leading to a loss of genetic material. They may also be formed by telomere-telomere fusions with no deletion, ...
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Article
Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates
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Article
The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability
Opioid analgesics remain the first choice for the treatment of moderate to severe pain, but they are also notorious for their respiratory depression and addictive effects. This study focused on the pharmacolog...
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Article
Open AccessLKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer
Germline and somatic mutations in STK11, the gene encoding the serine/threonine kinase LKB1, are strongly associated with tumorigenesis. While loss of LKB1 expression has been linked to breast cancer, the mechani...
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Article
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
Fanconi anemia is a genetic disease characterized by genomic instability and cancer predisposition1. Nine genes involved in Fanconi anemia have been identified; their products participate in a DNA damage–response...
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Article
X-linked inheritance of Fanconi anemia complementation group B
Fanconi anemia is an autosomal recessive syndrome characterized by diverse clinical symptoms, hypersensitivity to DNA crosslinking agents, chromosomal instability and susceptibility to cancer1,2. Fanconi anemia h...
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Article
A novel ubiquitin ligase is deficient in Fanconi anemia
Fanconi anemia is a recessively inherited disease characterized by congenital defects, bone marrow failure and cancer susceptibility1,2. Cells from individuals with Fanconi anemia are highly sensitive to DNA-cros...
