566 Result(s)

Article

Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time

The purpose of this study was to estimate both cross-sectional sibling recurrence risk ratio (λ _s ) and lifetime λ _s for the metabolic s...

Wei J Chen, Pi-Hua Liu, Yen-Yi Ho, Kuo-Liong Chien, Min-Tzu Lo… in BMC Genetics (2003)

Article

Construction of endophenotypes for complex diseases in the presence of heterogeneity

Endophenotypes such as behavior disorders have been increasingly adopted in genetic studies for complex traits. For efficient gene map**, it is essential that an endophenotype is associated with the disease ...

Chien-Hsiun Chen, Chih-Ling Kuo, Michael CP Lin, Yu-Jen Liang… in BMC Genetics (2005)

Article

On the attenuation and amplification of molecular noise in genetic regulatory networks

Noise has many important roles in cellular genetic regulatory functions at the nanomolar scale. At present, no good theory exists for identifying all possible mechanisms of genetic regulatory networks to atten...

Bor-Sen Chen, Yu-Chao Wang in BMC Bioinformatics (2006)

Article

SinicView: A visualization environment for comparisons of multiple nucleotide sequence alignment tools

Deluged by the rate and complexity of completed genomic sequences, the need to align longer sequences becomes more urgent, and many more tools have thus been developed. In the initial stage of genomic sequence...

Arthur Chun-Chieh Shih, DT Lee, Laurent Lin, Chin-Lin Peng… in BMC Bioinformatics (2006)

Article

Chromatin-binding in vivo of the erythroid kruppel-like factor, EKLF, in the murine globin loci

EKLF is an erythroid-specific, zinc finger-containing transcription factor essential for the activation of the mammalian beta globin gene in erythroid cells of definitive lineage. We have prepared a polyclonal...

Yu-Chiau Shyu, Shau-Ching Wen, Tung-Liang Lee, **n Chen, Chia-Tse Hsu… in Cell Research (2006)

Article

Protein disorder prediction by condensed PSSM considering propensity for order or disorder

More and more disordered regions have been discovered in protein sequences, and many of them are found to be functionally significant. Previous studies reveal that disordered regions of a protein can be predic...

Chung-Tsai Su, Chien-Yu Chen, Yu-Yen Ou in BMC Bioinformatics (2006)

Article

Comparison of transcripts in Phalaenopsis bellina and Phalaenopsis equestris(Orchidaceae) flowers to deduce monoterpene biosynthesis pathway

Floral scent is one of the important strategies for ensuring fertilization and for determining seed or fruit set. Research on plant scents has hampered mainly by the invisibility of this character, its dynamic...

Yu-Yun Hsiao, Wen-Chieh Tsai, Chang-Sheng Kuoh, Tian-Hsiang Huang… in BMC Plant Biology (2006)

Chapter and Conference Paper

Using Efficient RBF Network to Identify Interface Residues Based on PSSM Profiles and Biochemical Properties

Protein-protein interactions play a very important role in many biological processes, for example, information transfer along signaling pathways, and enzyme catalysis. Recently, scientists tried to predict the...

Yu-Yen Ou, Shu-An Chen, Chung-Lu Shao… in Pattern Recognition in Bioinformatics (2007)

Article

Binding of Sudan II and IV to lecithin liposomes and E. coli membranes: insights into the toxicity of hydrophobic azo dyes

Sudan red compounds are hydrophobic azo dyes, still used as food additives in some countries. However, they have been shown to be unsafe, causing tumors in the liver and urinary bladder in rats. They have been...

Lu Li, Hong-Wen Gao, Jiao-Rong Ren, Ling Chen, Yu-Cheng Li… in BMC Structural Biology (2007)

Article

Biotransformation of Cinobufagin by Cunninghamella elegans

Cunninghamella elegans has been employed for the biotransformation of cinobufagin to afford 5 metabolites. The structures of the transformation products have been characterized as 12α-hydroxybufagin, 11α-hydroxyb...

Li Qiao, Yu-zhi Zhou, **u-lan Qi, Li-hong Lin, Huan Chen… in The Journal of Antibiotics (2007)

Article

Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme

The development of microarrays permits us to monitor transcriptomes on a genome-wide scale. To validate microarray measurements, quantitative-real time-reverse transcription PCR (Q-RT-PCR) is one of the most r...

Li-Jen Su, Ching-Wei Chang, Yu-Chung Wu, Kuang-Chi Chen, Chien-Ju Lin… in BMC Genomics (2007)

Article

Solubilization of inorganic phosphates and plant growth promotion by Aspergillus niger

Chun-Chao Chuang, Yu-Lin Kuo, Chen-Ching Chao… in Biology and Fertility of Soils (2007)

Article

Prediction of mucin-type O-glycosylation sites in mammalian proteins using the composition of k-spaced amino acid pairs

As one of the most common protein post-translational modifications, glycosylation is involved in a variety of important biological processes. Computational identification of glycosylation sites in protein sequ...

Yong-Zi Chen, Yu-Rong Tang, Zhi-Ya Sheng, Ziding Zhang in BMC Bioinformatics (2008)

Article

Rapid EST isolation from chromosome 1R of rye

To obtain important expressed sequence tags (ESTs) located on specific chromosomes is currently difficult. Construction of single-chromosome EST library could be an efficient strategy to isolate important ESTs...

Ruo-Nan Zhou, Rui Shi, Shu-Mei Jiang, Wei-Bo Yin, Huang-Huang Wang… in BMC Plant Biology (2008)

Article

Overview of BioCreative II gene mention recognition

Nineteen teams presented results for the Gene Mention Task at the BioCreative II Workshop. In this task participants designed systems to identify substrings in sentences corresponding to gene name mentions. A ...

Larry Smith, Lorraine K Tanabe, Rie Johnson nee Ando, Cheng-Ju Kuo… in Genome Biology (2008)

Article

Construction of a chloroplast protein interaction network and functional mining of photosynthetic proteins in Arabidopsis thaliana

Chloroplast is a typical plant cell organelle where photosynthesis takes place. In this study, a total of 1 808 chloroplast core proteins in Arabidopsis thaliana were reliably identified by combining the results ...

Qing-Bo Yu, Guang Li, Guan Wang, **g-Chun Sun, Peng-Cheng Wang, Chen Wang… in Cell Research (2008)

Article

A systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises

Gene networks in nanoscale are of nonlinear stochastic process. Time delays are common and substantial in these biochemical processes due to gene transcription, translation, posttranslation protein modificatio...

Bor-Sen Chen, Yu-Te Chang in BMC Systems Biology (2008)

Article

The γ-gliadin multigene family in common wheat (Triticum aestivum) and its closely related species

The unique properties of wheat flour primarily depend on gluten, which is the most important source of protein for human being. γ-Gliadins have been considered to be the most ancient of the wheat gluten family...

Peng-Fei Qi, Yu-Ming Wei, Thérèse Ouellet, Qing Chen, **n Tan… in BMC Genomics (2009)

Article

LD₂SN**: linkage disequilibrium plotter and RFLP enzyme mining for tag SNPs

Linkage disequilibrium (LD) map** is commonly used to evaluate markers for genome-wide association studies. Most types of LD software focus strictly on LD analysis and visualization, but lack supporting serv...

Hsueh-Wei Chang, Li-Yeh Chuang, Yan-Jhu Chang, Yu-Huei Cheng, Yu-Chen Hung… in BMC Genetics (2009)

Article

Erratum: p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

Received 29 October 2008; accepted 19 February 2009; published online 17 May 2009; corrected after print 19 May 2009 In the version of this article initially published, the Myc–Ub label in Figure 3c was incorr...

Shu-** Wang, Wen-Lung Wang, Yih-Leong Chang, Chen-Tu Wu… in Nature Cell Biology (2009)