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    Article

    DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity

    Fluoropyrimidine drugs are widely used in head and neck cancer (HNC). DPD deficiency is a pharmacogenetics syndrome associated with severe/lethal toxicities upon 5-FU or capecitabine intake. We have developed ...

    Chen Guang Yang, Joseph Ciccolini, Aurore Blesius… in Cancer Chemotherapy and Pharmacology (2011)

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    Article

    Early severe toxicities after capecitabine intake: possible implication of a cytidine deaminase extensive metabolizer profile

    We report here the case of a 19-year-old female patient who suffered from extremely severe toxicities (G4 mucitis, fever, diarrhea, alteration of general state) while undergoing low-dose capecitabine treatment...

    Cedric Mercier, Charlotte Dupuis, Aurore Blesius… in Cancer Chemotherapy and Pharmacology (2009)