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Article
Open AccessAcceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds
Repairation of bone defects remains a major clinical problem. Constructing bone tissue engineering containing growth factors, stem cells, and material scaffolds to repair bone defects has recently become a hot...
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Article
Open AccessDomain generalization enables general cancer cell annotation in single-cell and spatial transcriptomics
Single-cell and spatial transcriptome sequencing, two recently optimized transcriptome sequencing methods, are increasingly used to study cancer and related diseases. Cell annotation, particularly for malignan...
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Article
Open AccessProbiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens
Baicalin and probiotic cocktails are promising feed additives with broad application prospects. While probiotic cocktails are known to enhance intestinal health, the potential synergistic impact of combining b...
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Article
Open AccessNorepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α2A-adrenergic receptor
The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIH...
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Article
Open AccessOptimal reconstruction methods after distal gastrectomy for gastric cancer: a protocol for a systematic review and network meta-analysis update
Distal gastrectomy (DG) is a commonly used surgical procedure for gastric cancer (GC), with three reconstruction methods available: Billroth I, Billroth II, and Roux-en-Y. In 2018, our team published a systema...
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Open AccessMiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis
In light of the abnormal expression of microRNA (miR-483-5p) in patients with atherosclerosis (AS), its role in vascular endothelial cell injury was explored. And the mechanisms related to autophagy were also ...
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Article
Open AccessCapturing nascent extracellular vesicles by metabolic glycan labeling-assisted microfluidics
Extracellular vesicle (EV) secretion is a dynamic process crucial to cellular communication. Temporally sorting EVs, i.e., separating the newly-produced ones from the pre-existing, can allow not only deep unde...
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Article
Open AccessAn innovative ensemble model based on deep learning for predicting COVID-19 infection
Nowadays, global public health crises are occurring more frequently, and accurate prediction of these diseases can reduce the burden on the healthcare system. Taking COVID-19 as an example, accurate prediction...
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Article
First-Principles Study on Thermoelectric Properties of Bi \(_2\) O \(_2\) Se
Compared with traditional thermoelectric (TE) materials, bismuth oxyselenide (Bi \(_2\) ...
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Article
Open AccessClinicopathological and mutational characteristics of primary double mutant gastrointestinal stromal tumor: a single center study with review of the literature
Primary double KIT/PDGFRA mutations are very rare in gastrointestinal stromal tumours (GISTs) but have not been comprehensively studied to date. In the present study, we investigated the clinicopathologic and ...
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Article
Open AccessWell-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics
Single-cell RNA sequencing (scRNA-seq) reveals the transcriptional heterogeneity of cells, but the static snapshots fail to reveal the time-resolved dynamics of transcription. Herein, we develop Well-TEMP-seq,...
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Article
Open AccessThe clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses
BRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further ...
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Article
Open AccessPrecipitation in eastern China over the past millennium varied with large-scale climate patterns
Modern precipitation variability over East China is known to be characterized by meridional tripole and dipole structures, linked to atmosphere and ocean dynamics. As the instrumental data may be influenced by...
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Article
Open AccessDeep transfer learning enables lesion tracing of circulating tumor cells
Liquid biopsy offers great promise for noninvasive cancer diagnostics, while the lack of adequate target characterization and analysis hinders its wide application. Single-cell RNA sequencing (scRNA-seq) is a ...
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Article
Open AccessClinical features and treatment outcome of lymphoepithelioma-like carcinoma from multiple primary sites: a population-based, multicentre, real-world study
Lymphoepithelioma-like carcinoma (LELC) is a rare and unique subtype of cancer that histologically resembles undifferentiated nasopharyngeal carcinoma (NPC). The population-based analysis of LELC and the optim...
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Article
Open AccessDoes epilepsy always indicate worse outcomes? A longitudinal follow-up analysis of 485 glioma patients
Epilepsy is one of the most common glioma complications, and the two may be connected in more ways than we understand. We aimed to investigate the clinical features of glioma-associated epilepsy and explore th...
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Article
Open AccessSuppressing high-dimensional crystallographic defects for ultra-scaled DNA arrays
While DNA-directed nano-fabrication enables the high-resolution patterning for conventional electronic materials and devices, the intrinsic self-assembly defects of DNA structures present challenges for furthe...
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Article
Open AccessDynamic changes of viral load and the duration of viral shedding in patients with hand, foot and mouth disease: a protocol for longitudinal study
The duration of virus shedding is necessary for determining the infectious period. But there were few quantitative studies on the changes of viral load and the law of the viral shedding in hand foot and mouth ...
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Article
Open AccessThe effect of levosimendan on right ventricular function in patients with heart dysfunction: a systematic review and meta-analysis
Levosimendan exerts positive inotropic and vasodilatory effects. Currently, its effects on right heart function remain uncertain. This systematic review and meta-analysis is intended to illustrate the impacts ...
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Article
Open AccessSurgical resection for patients with recurrent or metastatic gastrointestinal stromal tumors: a protocol for a systematic review and meta-analysis update
There are limited data on the clinical benefits of adding surgical resection in patients with recurrent or metastatic gastrointestinal stromal tumors (GISTs). This protocol outlines the planned scope and metho...
