23 Result(s)
within
Chaoyong **a
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessDomain generalization enables general cancer cell annotation in single-cell and spatial transcriptomics
Single-cell and spatial transcriptome sequencing, two recently optimized transcriptome sequencing methods, are increasingly used to study cancer and related diseases. Cell annotation, particularly for malignan...
-
Article
Open AccessCapturing nascent extracellular vesicles by metabolic glycan labeling-assisted microfluidics
Extracellular vesicle (EV) secretion is a dynamic process crucial to cellular communication. Temporally sorting EVs, i.e., separating the newly-produced ones from the pre-existing, can allow not only deep unde...
-
Article
Open AccessAn innovative ensemble model based on deep learning for predicting COVID-19 infection
Nowadays, global public health crises are occurring more frequently, and accurate prediction of these diseases can reduce the burden on the healthcare system. Taking COVID-19 as an example, accurate prediction...
-
Article
Open AccessWell-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics
Single-cell RNA sequencing (scRNA-seq) reveals the transcriptional heterogeneity of cells, but the static snapshots fail to reveal the time-resolved dynamics of transcription. Herein, we develop Well-TEMP-seq,...
-
Article
Open AccessDeep transfer learning enables lesion tracing of circulating tumor cells
Liquid biopsy offers great promise for noninvasive cancer diagnostics, while the lack of adequate target characterization and analysis hinders its wide application. Single-cell RNA sequencing (scRNA-seq) is a ...
-
Article
Open AccessSuppressing high-dimensional crystallographic defects for ultra-scaled DNA arrays
While DNA-directed nano-fabrication enables the high-resolution patterning for conventional electronic materials and devices, the intrinsic self-assembly defects of DNA structures present challenges for furthe...
-
Article
Open AccessThe effect of levosimendan on right ventricular function in patients with heart dysfunction: a systematic review and meta-analysis
Levosimendan exerts positive inotropic and vasodilatory effects. Currently, its effects on right heart function remain uncertain. This systematic review and meta-analysis is intended to illustrate the impacts ...
-
Article
Open Access3D-printed integrative probeheads for magnetic resonance
Magnetic resonance (MR) technology has been widely employed in scientific research, clinical diagnosis and geological survey. However, the fabrication of MR radio frequency probeheads still face difficulties i...
-
Article
Open AccessHighly parallel and efficient single cell mRNA sequencing with paired picoliter chambers
ScRNA-seq has the ability to reveal accurate and precise cell types and states. Existing scRNA-seq platforms utilize bead-based technologies uniquely barcoding individual cells, facing practical challenges for...
-
Article
Open AccessAssessing the viability of transplanted gut microbiota by sequential tagging with D-amino acid-based metabolic probes
Currently, there are more than 200 fecal microbiota transplantation (FMT) clinical trials worldwide. However, our knowledge of this microbial therapy is still limited. Here we develop a strategy using sequenti...
-
Article
Open AccessControl of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection
DNA hydrogels have received considerable attention in analytical science, however, some limitations still exist in the applications of intelligent hydrogels. In this paper, we describe a way to prepare gel fil...
-
Article
Open AccessOptimization of the co-digestion of sewage sludge, maize straw and cow manure: microbial responses and effect of fractional organic characteristics
The aim of this study was to evaluate the efficiency and optimization of co-digestion using sewage sludge (SS), maize straw (MS) and cow manure (CM) as feeds, and the effects of the mixing ratio and C/N ratio ...
-
Article
Open AccessEvaluation of the Heshang Cave stalagmite calcium isotope composition as a paleohydrologic proxy by comparison with the instrumental precipitation record
With their merits of precise dating and sensitivity to climate changes, laminated stalagmites are an important terrestrial archive for reconstructions of paleohydrological changes. In particular, the Ca isotop...
-
Article
Open AccessQuantum dot-like excitonic behavior in individual single walled-carbon nanotubes
Semiconducting single-walled carbon nanotubes are one-dimensional materials with great prospects for applications such as optoelectronic and quantum information devices. Yet, their optical performance is hinde...
-
Article
Open AccessUsing aptamers to elucidate esophageal cancer clinical samples
The epithelial cell adhesion molecule (EpCAM) is closely correlated with the occurrence and development of various cancers of epithelial origin. This study tested, for the first time, the ability of EpCAM apta...
-
Article
Open AccessMast Cells Participate in Corneal Development in Mice
The development of the cornea, a highly specialized transparent tissue located at the anterior of the eye, is coordinated by a variety of molecules and cells. Here, we report that mast cells (MCs), recently fo...
-
Article
PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis
Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (VSMCs). However, the direct effects of PDGF receptor β (PDGFRβ) activation on VSMCs have not been studie...
-
Article
Open AccessA Controllable Aptamer-Based Self-Assembled DNA Dendrimer for High Affinity Targeting, Bioimaging and Drug Delivery
Targeted drug delivery is important in cancer therapy to decrease the systemic toxicity resulting from nonspecific drug distribution and to enhance drug delivery efficiency. We have developed an aptamer-based ...
-
Article
Open AccessMicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1
MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target mRNAs. Current evidence indic...
-
Article
Retraction Note to: Early magnitude estimation for the MW7.9 Wenchuan earthquake using progressively expanded P-wave time window
More and more earthquake early warning systems (EEWS) are developed or currently being tested in many active seismic regions of the world. A well-known problem with real-time procedures is the parameter satura...
