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  1. No Access

    Article

    DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

    Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional activity. However, traditional bench-top protocols for single-cell DNA methylation and RNA tr...

    **ng Xu, ** Zeng, **n Lin, Shiyan Lin, Shanshan Liang, Tian Tian… in Science China Chemistry (2024)

  2. No Access

    Article

    Structural evolution and electronic properties of medium-sized CrSin−/0 (n = 19–25) clusters

    Herein, the structural evolution, electronic and magnetic properties of CrSin−/0 for n = 19–25 have been investigated at density functional theory (DFT) level. The global minimum structures of these clusters have...

    Kai Wang, Chaoyong Wang, Wei Li, Le Liu, Yarui Wang, Jiaye Chen… in Structural Chemistry (2024)

  3. No Access

    Article

    Beyond single cells: microfluidics empowering multiomics analysis

    Single-cell multiomics technologies empower simultaneous measurement of multiple types of molecules within individual cells, providing a more profound comprehension compared with the analysis of discrete molec...

    Tian Tian, Shichao Lin, Chaoyong Yang in Analytical and Bioanalytical Chemistry (2024)

  4. No Access

    Article

    Acid-accelerated hydrolysis of NaBH4: a gas-generation reaction for diverse gas pressure biosensing

    Gas pressure biosensing is a promising portable analysis method. The gas-generation reaction is crucial to its sensitivity, speed, repeatability, and usability. However, very few gas-generation reactions are a...

    Lu Shi, Qiaorong Tang, Bing Yang, Baoxin Li, Chaoyong Yang, Yan ** in Microchimica Acta (2023)

  5. No Access

    Living Reference Work Entry In depth

    Aptamer Molecular Evolution for Liquid Biopsy

    Liquid biopsy can provide comprehensive and real-time physiological and pathological information in a noninvasive and longitudinal monitoring manner, facilitating precision medicine practice and clinical inves...

    Lingling Wu, Qi Niu, Chaoyong Yang in Handbook of Chemical Biology of Nucleic Acids

  6. No Access

    Reference Work Entry In depth

    Aptamer Molecular Evolution for Liquid Biopsy

    Liquid biopsy can provide comprehensive and real-time physiological and pathological information in a noninvasive and longitudinal monitoring manner, facilitating precision medicine practice and clinical inves...

    Lingling Wu, Qi Niu, Chaoyong Yang in Handbook of Chemical Biology of Nucleic Acids (2023)

  7. No Access

    Article

    Nickel oxide thin film electrode synthesized by pneumatic spray pyrolysis with different NiCl2 concentration

    NiO has attracted much attention because of its environmental friendliness, high natural abundance, and theoretical specific capacity. The preparation of thin film electrode by pneumatic spray pyrolysis (PSP) ...

    Zhiyong Tang, Yun Ou, Chaoyong Ma, Chenqi Yao, Longfei Liu, Juanjuan Cheng in Ionics (2022)

  8. No Access

    Article

    Amplified visualization and function exploration of exosomal protein-specific glycosylation using hybridization chain reaction from non-functional epitope

    Exosomal glycoproteins play significant roles in many physiological and pathological procedures. However, the current methods for studying exosomal glycoproteins have low sensitivity or can affect exosomal bio...

    Siyin Kang, Lin Zhu, Wencheng Wang, Yinzhu Lu, Zhenlong You… in Science China Chemistry (2022)

  9. No Access

    Article

    In situ Raman enhancement strategy for highly sensitive and quantitative lateral flow assay

    As a paper-based analytical platform, lateral flow assay (LFA) gets benefit from the rapid analysis, low cost, high selectivity, good stability, and user-friendliness, and thus has been widely used in rapid sc...

    Haicong Shen, Eunyeong Song, Yang Wang… in Analytical and Bioanalytical Chemistry (2022)

  10. Article

    Analytical chemistry for infectious disease detection and prevention

    **uJun Li, Chaoyong Yang in Analytical and Bioanalytical Chemistry (2021)

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  11. Article

    Selection and applications of functional nucleic acids for infectious disease detection and prevention

    Infectious diseases caused by pathogenic microorganisms such as viruses and bacteria pose a great threat to human health. Although a significant progress has been obtained in the diagnosis and prevention of in...

    Lin Zhu, Jiajun Ling, Zhi Zhu, Tian Tian… in Analytical and Bioanalytical Chemistry (2021)

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  12. No Access

    Article

    Dispen-Seq: a single-microparticle dispenser based strategy towards flexible cell barcoding for single-cell RNA sequencing

    Single-cell RNA sequencing (scRNA-seq) has become one of the most powerful tools to understand the heterogeneity of biological systems. While barcoding strategies have revolutionized the field of high-throughp...

    Tian Tian, Yingwen Chen, Yunpeng Bi, **ngrui Li, MingXuan Gao… in Science China Chemistry (2021)

  13. Article

    Nucleic Acids Analysis

    Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysi...

    Yongxi Zhao, **aolei Zuo, Qian Li, Feng Chen, Yan-Ru Chen… in Science China Chemistry (2021)

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  14. No Access

    Article

    Crosstalk-free colloidosomes for high throughput single-molecule protein analysis

    Droplet microfluidics is a powerful platform for high-throughput single-molecule protein analysis. However, the issues of coalescence and crosstalk of droplets compromise the accuracy of detection and hinder i...

    Kun Yin, ** Zeng, Xuan Liang, Haopai Wei, Huimin Zeng, Wei Qi… in Science China Chemistry (2020)

  15. No Access

    Article

    Effects of Molecular Crowding on G-Quadruplex-hemin Mediated Peroxidase Activity

    The concentration of macromolecules in cells can reach up to 50–400 mg/mL. They occupy 40%(volume fraction) of the whole cellar space, known as molecular crowding. The diluted solution condition in vitro is diffe...

    Lu Liu, **gfang Lin, Yanling Song… in Chemical Research in Chinese Universities (2020)

  16. Article

    Open Access

    Reversed paired-gRNA plasmid cloning strategy for efficient genome editing in Escherichia coli

    Co-expression of two distinct guide RNAs (gRNAs) has been used to facilitate the application of CRISPR/Cas9 system in fields such as large genomic deletion. The paired gRNAs are often placed adjacently in the ...

    Tingting Ding, Chaoyong Huang, Zeyu Liang, **aoyan Ma… in Microbial Cell Factories (2020)

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  17. No Access

    Article

    A tridecaptin-based fluorescent probe for differential staining of Gram-negative bacteria

    The traditional Gram-staining method, which was invented more than a century ago for differentiating bacteria as Gram positive or Gram negative, is still widely practiced in microbiology. However, Gram stainin...

    Wei Wang, Yingyan Wang, Liyuan Lin, Yanling Song… in Analytical and Bioanalytical Chemistry (2019)

  18. No Access

    Article

    Portable detection of serum HER-2 in breast cancer by a pressure-based platform

    A high serum HER-2 extracellular domain (sHER-2 ECD) level has a reverse association with tumor behaviors. In this study, a portable platform for the disease biomarker sHER-2 ECD detection has been established...

    Qian Tao, **nyi Wu, Qingyuan Lin, Haiyan Zheng… in Analytical and Bioanalytical Chemistry (2018)

  19. No Access

    Article

    Selection and identification of transferrin receptor-specific peptides as recognition probes for cancer cells

    Since the transferrin receptor (CD71 or TFRC) is known to be highly expressed in numerous cancers, CD71 has become an attractive target in cancer research. Acquiring specific molecular probes for CD71, such as...

    Yuyu Tan, Wenli Liu, Zhi Zhu, Lijun Lang… in Analytical and Bioanalytical Chemistry (2018)

  20. No Access

    Article

    Target-responsive DNAzyme hydrogel for portable colorimetric detection of lanthanide(III) ions

    Lanthanide elements (Ln) play an important role in industry and agriculture. As a result of the increasing consumption of lanthanides, environmental emission of Ln has become detrimental to the health of flora...

    Yishun Huang, Xuemeng Wu, Tian Tian, Zhi Zhu, Hui Lin… in Science China Chemistry (2017)

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