23 Result(s)

Article

Acceptorless cross-dehydrogenative coupling for C(sp³)-H heteroarylation mediated by a heterogeneous GaN/ketone photocatalyst/photosensitizer system

Alkanes are naturally abundant chemical building blocks that contain plentiful C(sp³)-H bonds. While inert, the activation of C(sp³)-H via hydrogen atom abstraction (HAT) stages an appealing approach to generate ...

Hyotaik Kang, Lida Tan, **g-Tan Han, Chia-Yu Huang, Hui Su… in Communications Chemistry (2023)

Article

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice

The liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm of genes involved in lipid metabolism is also disturbed. Although the link between metabolism and circadian rhythms i...

**g Wu, Dandan Bu, Haiquan Wang, Di Shen, Danyang Chong… in Nature Communications (2023)

Article

Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

In the widely used Carbon tetrachloride (CCl₄)-induced acute liver injury (ALI) mouse model, hepatocytes are known to die from programmed cell death (PCD) processes including apoptosis and necroptosis. Both in vi...

Ke Lu, Si-Yu Shen, Ou-Yang Luo, Yue Lu, Tian-Shu Shi, **g Wu… in Cell Death & Disease (2022)

Article

Selective conversion of methane to cyclohexane and hydrogen via efficient hydrogen transfer catalyzed by GaN supported platinum clusters

Non-oxidative liquefaction of methane at room temperature and ambient pressure has long been a scientific “holy grail” of chemical research. Herein, we exploit an unprecedented catalytic transformation of meth...

Lida Tan, Hui Su, **gtan Han, Mingxin Liu, Chao-Jun Li in Scientific Reports (2022)

Article

MYPT1 reduction is a pathogenic factor of erectile dysfunction

Erectile dysfunction (ED) is closely associated with smooth muscle dysfunction, but its underlying mechanisms remains incompletely understood. We here reported that the reduced expression of myosin phosphatase...

Wei Zhao, Jie Sun, Liang-Yu Yao, Dong Hang, Ye-Qiong Li… in Communications Biology (2022)

Article

Light-driven transition-metal-free direct decarbonylation of unstrained diaryl ketones via a dual C–C bond cleavage

The cleavage and formation of carbon−carbon bonds have emerged as powerful tools for structural modifications in organic synthesis. Although transition−metal−catalyzed decarbonylation of unstrained diaryl keto...

Dawei Cao, Mohamad Ataya, Zhangpei Chen, Huiying Zeng, Yong Peng… in Nature Communications (2022)

Article

Urinary levels of dimethoate, bisphenol A and benzo[a]pyrene in first-year students of Hohai University from different geographical regions

The objective of this study was to detect the urinary levels of dimethoate, benzo(a) pyrene (BaP), and bisphenol A (BPA) in first-year Hohai University students with different geographic origins.

Yu-Juan Xu, Hong-Liang Gao, He Liu, Ning-Wei Zhao, Qi Cheng… in BMC Public Health (2021)

Article

Direct deoxygenative borylation of carboxylic acids

Carboxylic acids are readily available, structurally diverse and shelf-stable; therefore, converting them to the isoelectronic boronic acids, which play pivotal roles in different settings, would be highly ena...

Jianbin Li, Chia-Yu Huang, Mohamad Ataya, Rustam Z. Khaliullin… in Nature Communications (2021)

Article

A cross-dehydrogenative C(sp³)−H heteroarylation via photo-induced catalytic chlorine radical generation

Hydrogen atom abstraction (HAT) from C(sp³)–H bonds of naturally abundant alkanes for alkyl radical generation represents a promising yet underexplored strategy in the alkylation reaction designs since involving ...

Chia-Yu Huang, Jianbin Li, Chao-Jun Li in Nature Communications (2021)

Article

C(sp³)−C(sp³) bond formation via nickel-catalyzed deoxygenative homo-coupling of aldehydes/ketones mediated by hydrazine

Aldehydes and ketones are widely found in biomass resources and play important roles in organic synthesis. However, the direct deoxygenative coupling of aldehydes or ketones to construct C(sp³)−C(sp³) bond remain...

Dawei Cao, Chen-Chen Li, Huiying Zeng, Yong Peng, Chao-Jun Li in Nature Communications (2021)

Article

Empowering alcohols as carbonyl surrogates for Grignard-type reactions

The Grignard reaction is a fundamental tool for constructing C-C bonds. Although it is widely used in synthetic chemistry, it is normally applied in early stage functionalizations owing to poor functional grou...

Chen-Chen Li, Haining Wang, Malcolm M. Sim, Zihang Qiu… in Nature Communications (2020)

Article

Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

Lipid overload results in lipid redistribution among metabolic organs such as liver, adipose, and muscle; therefore, the interplay between liver and other organs is important to maintain lipid homeostasis. Her...

Yue Zhao, Meng-Fei Zhao, Shan Jiang, **g Wu, Jia Liu… in Nature Communications (2020)

Article

Direct dehydrogenative alkyl Heck-couplings of vinylarenes with umpolung aldehydes catalyzed by nickel

Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides...

Leiyang Lv, Dianhu Zhu, Chao-Jun Li in Nature Communications (2019)

Article

N₂H₄ as traceless mediator for homo- and cross- aryl coupling

Transition-metal catalyzed couplings of aryl halides or arenes with aryl organometallics, as well as direct reductive coupling of two aryl halides, are the predominant methods to synthesize biaryls. However, s...

Leiyang Lv, Zihang Qiu, Jianbin Li, Mingxin Liu, Chao-Jun Li in Nature Communications (2018)

Article

Catalytic N-modification of α-amino acids and small peptides with phenol under bio-compatible conditions

The functionalization of α-amino acids and peptides provides the opportunity to tailor the properties of these biomolecules for diverse applications in chemistry and biology. Previous methods for N-modification i...

Alejandra Dominguez-Huerta, Inna Perepichka, Chao-Jun Li in Communications Chemistry (2018)

Article

Bi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints

Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. And a BET protein inhibitor, I-BET151, has...

** Dai, Sheng Zhou, Qiting Ge, **zhong Qin… in Journal of Orthopaedic Surgery and Research (2018)

Article

Addendum: Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

Haining Wang, **-Jie Dai, Chao-Jun Li in Nature Chemistry (2017)

Article

Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice

Spermatogenesis in adulthood depends on the successful neonatal establishment of the spermatogonial stem cell (SSC) pool and gradual differentiation during puberty. The stage-dependent changes in protein preny...

Fan Diao, Chen Jiang, **u-**ng Wang, Rui-Lou Zhu, Qiang Wang… in Scientific Reports (2016)

Article

EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription

The mammalian clock system is composed of a master clock and peripheral clocks. At the molecular level, the rhythm-generating mechanism is controlled by a molecular clock composed of positive and negative feed...

Weiwei Tao, **g Wu, Qian Zhang, Shan-Shan Lai, Shan Jiang… in Scientific Reports (2015)

Article

GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis

Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to...

De-cai Yu, Jia Liu, Jun Chen, Jiao-jiao Shao, **ao Shen, Hong-guang **a… in BMC Cancer (2014)