15 Result(s)
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Article
The Barbier–Grignard-type arylation of aldehydes using unactivated aryl iodides in water
Carbon–carbon bond formation is the essence of organic synthesis. One of the most important methods for forming carbon–carbon bonds is the Barbier–Grignard-type reaction, which was discovered over a century ag...
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Empowering a transition-metal-free coupling between alkyne and alkyl iodide with light in water
Methods to assemble alkynes are essential for synthesizing fine chemicals, pharmaceuticals and polymeric photo-/electronic materials. Using light as a clean energy form and water as a green solvent has the pot...
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Article
Open AccessEGR1 regulates hepatic clock gene amplitude by activating Per1 transcription
The mammalian clock system is composed of a master clock and peripheral clocks. At the molecular level, the rhythm-generating mechanism is controlled by a molecular clock composed of positive and negative feed...
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Open AccessAlteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice
Spermatogenesis in adulthood depends on the successful neonatal establishment of the spermatogonial stem cell (SSC) pool and gradual differentiation during puberty. The stage-dependent changes in protein preny...
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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
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Open AccessN2H4 as traceless mediator for homo- and cross- aryl coupling
Transition-metal catalyzed couplings of aryl halides or arenes with aryl organometallics, as well as direct reductive coupling of two aryl halides, are the predominant methods to synthesize biaryls. However, s...
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Open AccessDirect dehydrogenative alkyl Heck-couplings of vinylarenes with umpolung aldehydes catalyzed by nickel
Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides...
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Open AccessLiver governs adipose remodelling via extracellular vesicles in response to lipid overload
Lipid overload results in lipid redistribution among metabolic organs such as liver, adipose, and muscle; therefore, the interplay between liver and other organs is important to maintain lipid homeostasis. Her...
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Article
Open AccessEmpowering alcohols as carbonyl surrogates for Grignard-type reactions
The Grignard reaction is a fundamental tool for constructing C-C bonds. Although it is widely used in synthetic chemistry, it is normally applied in early stage functionalizations owing to poor functional grou...
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Open AccessC(sp3)−C(sp3) bond formation via nickel-catalyzed deoxygenative homo-coupling of aldehydes/ketones mediated by hydrazine
Aldehydes and ketones are widely found in biomass resources and play important roles in organic synthesis. However, the direct deoxygenative coupling of aldehydes or ketones to construct C(sp3)−C(sp3) bond remain...
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Article
Open AccessA cross-dehydrogenative C(sp3)−H heteroarylation via photo-induced catalytic chlorine radical generation
Hydrogen atom abstraction (HAT) from C(sp3)–H bonds of naturally abundant alkanes for alkyl radical generation represents a promising yet underexplored strategy in the alkylation reaction designs since involving ...
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Article
Open AccessDirect deoxygenative borylation of carboxylic acids
Carboxylic acids are readily available, structurally diverse and shelf-stable; therefore, converting them to the isoelectronic boronic acids, which play pivotal roles in different settings, would be highly ena...
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Open AccessLight-driven transition-metal-free direct decarbonylation of unstrained diaryl ketones via a dual C–C bond cleavage
The cleavage and formation of carbon−carbon bonds have emerged as powerful tools for structural modifications in organic synthesis. Although transition−metal−catalyzed decarbonylation of unstrained diaryl keto...
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Open AccessSelective conversion of methane to cyclohexane and hydrogen via efficient hydrogen transfer catalyzed by GaN supported platinum clusters
Non-oxidative liquefaction of methane at room temperature and ambient pressure has long been a scientific “holy grail” of chemical research. Herein, we exploit an unprecedented catalytic transformation of meth...
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Open AccessThe rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice
The liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm of genes involved in lipid metabolism is also disturbed. Although the link between metabolism and circadian rhythms i...
