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Article

Bi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints

Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. And a BET protein inhibitor, I-BET151, has...

** Dai, Sheng Zhou, Qiting Ge, **zhong Qin… in Journal of Orthopaedic Surgery and Research (2018)